Investigator

Role Summary

We are seeking applications from a talented and driven Investigator to join our Respiratory Immunology Inflammatory Research Unit (RIIRU) at GSK's Upper Providence research facility. The mission for RIIRU is to target diseases by harnessing the power of the immune system. The ideal candidate will work within a dynamic team to support research in neurodegenerative diseases (ND) such as AD, PD, and ALS. This full-time, lab-based position requires a PhD and at least three years of postdoctoral or industry experience with a passion for science and drug development.

Responsibilities

• Support discovery projects by establishing and performing in vitro iPSC derived CNS cells/ ex vivo cellular assays using high-content imaging, molecular and biochemical readouts.
• Develop novel assays with high translational value to interrogate target or disease biology
• Develop target and biomarker hypothesis based on Omics data
• Optimize and perform in vitro assays to support lead optimization of molecules
• Work collaboratively with matrix partners to drive towards project milestone
• Periodically update work status to project teams and matrix partners
• Manage time efficiently and be productive when there are competing priorities
• Be compliant with GSK policies and SOPs including recording electronic laboratory notebooks, maintaining safety while working in the lab.

Qualifications

• Required: PhD with 3+ years of postdoctoral experience in Neuroscience/Neurodegeneration
• Required: Experience with aseptic cell culture techniques especially for long term culture without antibiotics
• Required: Experience with standard laboratory techniques such as immunofluorescence assay, plate- or bead-based immunoassay, molecular biology techniques such as western, qPCR, transfection, or high content imaging
• Required: Experience in developing assays based on target mechanisms/ biology in the context of neurodegeneration
• Required: Experience with AI/ML tools for discovery research

• Preferred: 3+ years’ industry experience working in matrix environment
• Preferred: Working experience with iPSC derived neurons/ astrocytes/ microglia for disease modeling
• Preferred: Familiarity with different screening platforms used in drug discovery
• Preferred: Basic hands on bioinformatic skills
• Preferred: Effective communication skills and being proactive at work

Additional Requirements

• This position requires on-site attendance five days per week at our Upper Providence office