Information Technology Infrastructure Manager
Lyell Immunopharma
July 02, 2026
Remote friendly (South San Francisco, CA)
United States
IT
Position Summary:
Internal technical expert (hands-on individual contributor) for infrastructure, cloud, identity, and collaboration environments in a regulated life sciences setting.
Key Responsibilities:
- Design/build infrastructure across AWS, on-premises, networking, identity, and collaboration.
- Translate approved architectures into configurations/implementation plans; validate and transition steady-state operations to the MSP while retaining ownership.
- Provide technical input to IT architecture standards, strategy, roadmap; maintain documentation.
- Own and optimize AWS (governance, cost management, security controls).
- Configure/maintain on-prem: VMware vSphere, Windows Server, Active Directory, and networking (routing/switching/firewall/segmentation).
- Ensure backup/DR integrity (e.g., Veeam), monitor backup health, resolve exceptions; manage VPN/telecom.
- Govern Okta, Microsoft 365, Zoom, and Slack to meet security/audit/compliance needs.
- Support lab infrastructure (software + instrumentation).
- Primary day-to-day technical authority for the MSP; oversee SLA/ITIL-aligned incident/problem/change/request management.
- Tier 3 escalation for complex infrastructure incidents.
- Participate in vendor evaluations/SOW reviews and contract governance.
- Own security tooling configuration (EDR/SIEM) and support CSV/validated, audit-ready operations.
- Admin/govern enterprise AI platforms (primarily Anthropic Claude) with access/policy controls and responsible, audit-ready use.
Preferred Education & Experience (Required/Preferred):
- BA/BS IT (or equivalent); 10+ years IT infrastructure, including 8+ years solution architecture/design/implementation across cloud/on-prem/networking.
- Life sciences/biotech experience; understanding of GxP/validated systems.
- Deep AWS expertise; Windows Server/VMware vSphere/Active Directory experience.
- Okta/Microsoft 365/Zoom/Slack administration/governance.
- Network administration fundamentals; experience with Cisco Meraki and/or Palo Alto Networks.
- Backup/DR (Veeam), VPN/telecom/video conferencing experience.
- Scripting/automation (Python/PowerShell/Ruby or equivalent) and/or automation tools.
- MSP/third-party oversight; Tier 3 escalation experience.
- Enterprise AI platform administration/governance familiarity (Anthropic Claude or equivalent).
Knowledge, Skills & Abilities:
- Comfortable hands-on daily execution and incident resolution.
- Strong vendor management by influence; strong problem-solving/communication/documentation.
- Preferred: AWS certifications; infrastructure-as-code (Terraform/CloudFormation or equivalent).
Compensation/Benefits:
- Salary: $175,000–$195,000 annually; bonus opportunity.
- Eligible for Lyell’s Equity Incentive Plan.
Application Instruction:
- If interested and think you could fit, please apply.
Internal technical expert (hands-on individual contributor) for infrastructure, cloud, identity, and collaboration environments in a regulated life sciences setting.
Key Responsibilities:
- Design/build infrastructure across AWS, on-premises, networking, identity, and collaboration.
- Translate approved architectures into configurations/implementation plans; validate and transition steady-state operations to the MSP while retaining ownership.
- Provide technical input to IT architecture standards, strategy, roadmap; maintain documentation.
- Own and optimize AWS (governance, cost management, security controls).
- Configure/maintain on-prem: VMware vSphere, Windows Server, Active Directory, and networking (routing/switching/firewall/segmentation).
- Ensure backup/DR integrity (e.g., Veeam), monitor backup health, resolve exceptions; manage VPN/telecom.
- Govern Okta, Microsoft 365, Zoom, and Slack to meet security/audit/compliance needs.
- Support lab infrastructure (software + instrumentation).
- Primary day-to-day technical authority for the MSP; oversee SLA/ITIL-aligned incident/problem/change/request management.
- Tier 3 escalation for complex infrastructure incidents.
- Participate in vendor evaluations/SOW reviews and contract governance.
- Own security tooling configuration (EDR/SIEM) and support CSV/validated, audit-ready operations.
- Admin/govern enterprise AI platforms (primarily Anthropic Claude) with access/policy controls and responsible, audit-ready use.
Preferred Education & Experience (Required/Preferred):
- BA/BS IT (or equivalent); 10+ years IT infrastructure, including 8+ years solution architecture/design/implementation across cloud/on-prem/networking.
- Life sciences/biotech experience; understanding of GxP/validated systems.
- Deep AWS expertise; Windows Server/VMware vSphere/Active Directory experience.
- Okta/Microsoft 365/Zoom/Slack administration/governance.
- Network administration fundamentals; experience with Cisco Meraki and/or Palo Alto Networks.
- Backup/DR (Veeam), VPN/telecom/video conferencing experience.
- Scripting/automation (Python/PowerShell/Ruby or equivalent) and/or automation tools.
- MSP/third-party oversight; Tier 3 escalation experience.
- Enterprise AI platform administration/governance familiarity (Anthropic Claude or equivalent).
Knowledge, Skills & Abilities:
- Comfortable hands-on daily execution and incident resolution.
- Strong vendor management by influence; strong problem-solving/communication/documentation.
- Preferred: AWS certifications; infrastructure-as-code (Terraform/CloudFormation or equivalent).
Compensation/Benefits:
- Salary: $175,000–$195,000 annually; bonus opportunity.
- Eligible for Lyell’s Equity Incentive Plan.
Application Instruction:
- If interested and think you could fit, please apply.