In Vivo Pharmacologist- Immunology

Role Summary

In Vivo Pharmacologist- Immunology at Lilly’s Biotechnology Center in San Diego, leading research studies to understand immunological mechanisms using advanced in vivo models to enable drug discovery efforts. Expertise in humanized mouse systems, particularly CD34+ hematopoietic stem cell engraftment, is essential.

Responsibilities

• Provide strong scientific and technical leadership to establish and innovate in in vivo models to interrogate mechanisms and pathways relevant to the discovery of novel treatments for autoimmune diseases and related pathologies.
• Be hands-on in the laboratory to leverage and develop in vivo and in vitro systems to generate critical data supporting new and existing programs. Must be skilled with human CD34+ hematopoietic stem cell engraftment.
• Function independently, work within a team-oriented lab environment and communicate results to cross functional discipline teams.
• Provide supervision and mentoring to 1-2 scientists, performance evaluations, and career development.
• Requirement for accurate record keeping, independent data analysis, and reporting of data in written and oral formats. Will perform work in full compliance with Lilly Research Policies and complete all required training activities in the timeframe specified.

Qualifications

• Ph.D. in physiology, immunology, biology, pharmacology, or a closely related field
• 1-2 years' experience with in-vivo capabilities and human CD34+

Additional Skills

• Strong/extensive in vivo capabilities
• Skilled in the art of human CD34+ hematopoietic stem cell engraftment into mice and execution of downstream studies
• Proficient in cell isolation, cell culture, and immune cell differentiation procedures
• Knowledgeable with ex vivo sample assays and analyses (e.g. ELISA, RNA isolation, Nanostring)
• Familiarity with FACS and immunophenotyping
• Ability to prioritize activities across multiple projects independently and effectively while demonstrating initiative and appropriate risk taking
• Excellent communication and organizational skills to present findings in internal and external forums