Human Genetics Laboratory Leader

Role: Lead a Human Genetics research team as Senior Principal Scientist or Associate Director, focusing on translating human genetic insights into biological hypotheses to inform target discovery across disease areas. Responsibilities include managing a small team of 2-3 scientists, establishing experimental capabilities for variant characterization, and applying genetics expertise to enable recall-by-genotype strategies using biobank resources. The role involves developing and executing genotype-to-phenotype research strategies, interpreting genetic data to inform target prioritization, and contributing to cross-functional decision-making and governance. Requirements: PhD with 8+ years’ experience in genetics, particularly in rare variants and genotype-to-phenotype translation; strong background in cellular models and gene perturbation; proven leadership and collaboration skills; curiosity for emerging AI and genomics technologies. Desirable: experience in recall-by-genotype studies and drug discovery. High-Value: genetics (rare variants, biobank data), functional biology, human genetics mechanisms, target validation, cross-disciplinary collaboration, onsite in Cambridge, MA.