Human Genetics Laboratory Leader
Novartis
July 03, 2026
On-site
Cambridge, MA
Clinical Research and Development
Key Responsibilities:
- Lead and develop a team of 2–3 wet lab scientists; establish experimental capabilities to functionally characterize human genetic variation.
- Manage resources, priorities, and execution across multiple projects to ensure high-quality data generation, interpretation, and delivery.
- Enable recall-by-genotype strategies, including participant identification from biobank resources and design of deep phenotyping protocols.
- Evolve the genotype-to-phenotype strategy by translating rare variants into biological hypotheses and target investment decisions.
- Represent genetics expertise in cross-functional teams and governance boards for portfolio prioritization.
- Build and maintain internal/external partnerships and communicate scientific insights to diverse audiences.
Essential Requirements:
- PhD with 8+ years post-graduate experience in genetics, focused on rare variants and/or genotype-to-phenotype translation.
- Strong experimental biology background (cellular models; gene perturbation technologies for variant characterization).
- Extensive experience linking clinical/biobank genetic data to biological mechanisms and therapeutic hypotheses across disease areas.
- Proven people leadership/mentoring skills; ability to influence in a matrix environment.
- Interest in emerging methods, including AI-based variant interpretation/prioritization.
- Exceptional collaboration, communication, and problem-solving; strong track record of scientific innovation.
Desirable Requirements:
- Hands-on experience designing/executing recall-by-genotype studies.
- Target and/or drug discovery industry experience.
Compensation (expected): $138,600–$257,400 (Senior Principal Scientist) or $152,600–$283,400 (Associate Director) annually, plus performance-based cash incentive; annual equity may be available.
Location: Cambridge, MA (onsite). Relocation support not provided.
- Lead and develop a team of 2–3 wet lab scientists; establish experimental capabilities to functionally characterize human genetic variation.
- Manage resources, priorities, and execution across multiple projects to ensure high-quality data generation, interpretation, and delivery.
- Enable recall-by-genotype strategies, including participant identification from biobank resources and design of deep phenotyping protocols.
- Evolve the genotype-to-phenotype strategy by translating rare variants into biological hypotheses and target investment decisions.
- Represent genetics expertise in cross-functional teams and governance boards for portfolio prioritization.
- Build and maintain internal/external partnerships and communicate scientific insights to diverse audiences.
Essential Requirements:
- PhD with 8+ years post-graduate experience in genetics, focused on rare variants and/or genotype-to-phenotype translation.
- Strong experimental biology background (cellular models; gene perturbation technologies for variant characterization).
- Extensive experience linking clinical/biobank genetic data to biological mechanisms and therapeutic hypotheses across disease areas.
- Proven people leadership/mentoring skills; ability to influence in a matrix environment.
- Interest in emerging methods, including AI-based variant interpretation/prioritization.
- Exceptional collaboration, communication, and problem-solving; strong track record of scientific innovation.
Desirable Requirements:
- Hands-on experience designing/executing recall-by-genotype studies.
- Target and/or drug discovery industry experience.
Compensation (expected): $138,600–$257,400 (Senior Principal Scientist) or $152,600–$283,400 (Associate Director) annually, plus performance-based cash incentive; annual equity may be available.
Location: Cambridge, MA (onsite). Relocation support not provided.