Head, Project Management & Program Management

Role Summary

Location: This role can be based on-site in Miami, FL, or in Menlo Park, CA, or Princeton, NJ.

Reporting to the Chief Business & Strategy Officer, the Head of Project Management & Program Management will lead the project management office (PMO) responsible for cross-functional strategic and operational execution of development and ultimate regulatory approval and commercialization of ivonescimab. They will be responsible for driving cross-functional alignment, ensuring delivery of clinical development plans from Phase I through Phase III, and supporting regulatory filings including BLA, MAA, and other global submissions. The Head is accountable for establishing and maintaining an integrated project plan to cover all aspects of the ivonescimab development program(s), including clinical development, regulatory, biometrics, clinical operations, medical affairs, CMC / manufacturing, and commercial.

This leader will shape and oversee the Project Management and Program Management function, building best-in-class project & program management practices and strategic approaches in securing appropriate resources to drive results. They will lead and mentor a team of program and project management professionals and foster strong partnerships across internal teams and external collaborators, including co-development & licensing partners, CROs, and regulatory bodies to ensure program success and maximize portfolio value.

Responsibilities

• Lead a high-performing Project Management Office that supports strategic planning and execution across all development programs.
• Oversee & define the integrated program plan covering Phase I-III trials and regulatory filings
• Lead cross-functional teams including Clinical, Regulatory, Medical Affairs, CMC, Operations, and Commercial to align on strategy, resolve issues, and drive execution.
• Oversee planning and execution of multiple clinical trials, ensuring readiness for regulatory filings and inspection preparedness.
• Facilitate decision-making processes, including risk mitigation strategies, plan amendments, and scenario planning.
• Present updates, risks, and strategic recommendations to the Executive Leadership Team and other senior stakeholders regarding ivonescimab.
• Mentor and develop project managers and program leads, fostering a culture of accountability, innovation, and continuous improvement.
• Driving strategic alignment for development, research, manufacturing, regulatory, medical affairs, market access, pricing and commercialization plans
• All other duties as assigned

Qualifications

• Advanced Degree (Ph.D., M.D., Pharm.D., MBA, or applicable master’s degree) with at least 15+ years of pharmaceutical / biotech industry experience, including leadership experience in program management or similar function, is required.
• Proven leadership in project management and program management across Phase I-III clinical trials.
• Experience in cross-functional team leadership, including strategy development and driving tactical delivery of programs.
• Strong experience in drug development and late-stage registration required, oncology experience strongly preferred.
• Deep understanding of regulatory pathways and commercialization strategies.
• Exceptional communication, negotiation, and stakeholder management skills.