Head of Global Investigative Toxicology

Role Summary

Head of Global Investigative Toxicology leading global investigative toxicology efforts with operations in multiple sites, shaping strategy and driving translational safety assessment for novel drug targets.

Responsibilities

• Leading our global investigative toxicology efforts with operations in Boston, Paris and Montpellier and with Senior Scientific Advisors serving as global safety experts in various toxicology disciplines based in multiple countries; develop/evolve strategy, ensure alignment and rationalization of activities across sites; ensure access to methodologies/vendors; collaborate with other R&D functions to share technologies and synergies; advise Preclinical Safety Project teams on building investigative toxicology strategy and review strategies to progress projects.
• Reporting to global Head PCS and member of the global Leadership Team.
• Manage Senior Scientific Advisors globally.
• Interact with Heads of Research Projects and Development projects.
• Develop innovative solutions and research proposals to optimize translational safety assessment of novel drug targets.
• Facilitate and promote the use of NAMs in preclinical safety testing.
• Serve as internal expert for discovery and development projects; design project-specific strategies to predict, assess and mitigate safety risks and execute through internal and external capabilities.
• Engage with experts across the organization to ensure informed decisions regarding translational safety risks.
• Collaborate with multiple R&D functions to identify opportunities to utilize technologies across R&D more efficiently.
• Participate in special projects or inter-industry groups; provide scientific input on research design and analysis; contribute to outreach activities.
• Ensure high scientific standards and timelines; supervise and develop laboratory staff and global experts.

Qualifications

• PhD or DVM with post-doctoral experience in toxicology, biochemistry, pharmacology, cell biology, or systems biology; knowledge across biochemistry, toxicology, pharmacology, biology, physiology, and pathology.
• More than 20 years of experience in pharmaceutical industry in nonclinical drug safety and investigative toxicology.
• Demonstrated knowledge of investigating molecular mechanisms of drug action; experience designing and executing in vitro/in vivo experiments to assess effects of therapeutics on biological systems with human safety risk context.
• Knowledge of regulatory nonclinical testing requirements for biologics and small molecules.
• Strong leadership competencies as a direct manager and transversal leader in a global environment.

Preferred Qualifications

• Motivated, creative, collaborative scientist with a team-oriented mindset.
• Strong communication, presentation and influencing skills.
• DABT certification and GLP Study Director experience preferred but not required.