Head of Global Investigative Toxicology

Role Summary

Head of Global Investigative Toxicology. Lead global investigative toxicology efforts across multiple sites, develop and align strategy, manage Senior Scientific Advisors, and advance translational safety assessment of novel drug targets. Collaborate across R&D functions to implement innovative safety approaches and NEW Alternative Methodologies (NAMs) in preclinical safety.

Responsibilities

• Leading our global investigative toxicology efforts with operations in Boston, Paris and Montpellier and with Senior Scientific Advisors serving as global safety experts in various toxicology disciplines; develop/evolve strategy, ensure alignment and rationalization of activities across sites; build networks with internal and external partners and ensure access to methodologies/vendors; collaborate with Translational Medicine Unit and other R&D functions to share technologies and leverage synergies. Advise Preclinical Safety teams on strategy and progress decisions.
• Reporting to global Head PCS and serving as a Member of the global Leadership Team.
• Manage Senior Scientific Advisors globally.
• Interact with Heads of Research Projects and Development projects to align safety strategy with discovery efforts.
• Develop innovative solutions and proposals to optimize translational safety assessment of novel drug targets.
• Facilitate and promote the use of NAMs in preclinical safety regulatory and non-regulatory testing.
• Serve as an internal expert for discovery and development projects; design project-specific strategies to predict, assess and mitigate safety risks and execute through internal and external capabilities.
• Engage with experts across the organization to inform translational safety decisions.
• Collaborate with multiple R&D functions to identify opportunities for cross-functional technology utilization.
• Participate in special projects or industry groups; provide scientific input on study design and analysis; contribute to outreach activities.
• Maintain high scientific standards and adhere to timelines; supervise and develop laboratory staff and global experts.

Qualifications

• Required: PhD or DVM with post-doctoral experience in toxicology, biochemistry, pharmacology, cell biology, or systems biology; broad knowledge in biochemistry, toxicology, pharmacology, biology, physiology, and pathology.
• Required: >20 years of experience in the pharmaceutical industry in nonclinical drug safety and investigative toxicology; strong understanding of drug discovery and development processes.
• Required: Demonstrated knowledge of molecular mechanisms of drug action; experience designing and executing in vitro/in vivo experiments to assess safety risk.
• Required: Knowledge of regulatory nonclinical testing requirements for biologics and small molecules; strong leadership capabilities in a global environment.
• Preferred: DABT certification and experience as GLP Study Director; strong leadership and collaboration skills; excellent communication, presentation, and influencing abilities.

Education

• PhD or DVM and post-doctoral experience in toxicology, biochemistry, pharmacology, cell biology, or systems biology; extensive experience in drug safety and investigative toxicology.