Head of DMPK
Recursion
12 hours ago
Remote friendly (Salt Lake City, UT)
United States
Clinical Research and Development
Your Impact
- Strategic Leadership: Define and execute DMPK strategy for a diverse therapeutic area portfolio (primarily small molecules; agility for peptides, ADCs, proximity-inducing therapeutics).
- Scientific Rigor and Project Acceleration: Ensure excellence as programs move into development, including robust human dose projections, DDI assessments, and translational PK/PD strategies.
- Tech-Forward Collaboration: Partner with Data Science/ML to refine predictive ADME models to prioritize compounds and de-risk the portfolio.
- External Partnerships: Serve as a strategic subject matter expert for high-stakes external partnerships with transparency and technical rigor.
- Talent Development: Develop and lead a high-performing team; amplify team capabilities via active learning and rapid adaptation.
- Cross-Functional Synergy: Partner with Toxicology, Translation, and Design to integrate DMPK insights into target validation and lead optimization.
Who You Are
- PhD (or equivalent) in Pharmacokinetics, Drug Metabolism, Pharmacology, or related field.
- 15+ years track record moving programs from Discovery to Development (pharma/biotech).
- Deep small-molecule DMPK expertise; ADC/peptide/proximity-inducing experience is a plus.
- Familiar with IND submission requirements and regulatory interactions.
- Strong collaborative leadership; comfortable across biology and technology.
Technical Skills & Expertise
- In vitro/in vivo ADME and contemporary PK/PD modeling; experience supporting CNS exposure and/or restricting peripheral exposure.
- Human PK and efficacious dose prediction.
- Manage CROs for quality data and timely delivery; biotransformation/metabolic pathway knowledge.
Working Location & Compensation
- Hybrid office role (50% in office) in Salt Lake City or New York City. Base salary range: $284,900–$400,950; bonus, equity, and comprehensive benefits.
- Strategic Leadership: Define and execute DMPK strategy for a diverse therapeutic area portfolio (primarily small molecules; agility for peptides, ADCs, proximity-inducing therapeutics).
- Scientific Rigor and Project Acceleration: Ensure excellence as programs move into development, including robust human dose projections, DDI assessments, and translational PK/PD strategies.
- Tech-Forward Collaboration: Partner with Data Science/ML to refine predictive ADME models to prioritize compounds and de-risk the portfolio.
- External Partnerships: Serve as a strategic subject matter expert for high-stakes external partnerships with transparency and technical rigor.
- Talent Development: Develop and lead a high-performing team; amplify team capabilities via active learning and rapid adaptation.
- Cross-Functional Synergy: Partner with Toxicology, Translation, and Design to integrate DMPK insights into target validation and lead optimization.
Who You Are
- PhD (or equivalent) in Pharmacokinetics, Drug Metabolism, Pharmacology, or related field.
- 15+ years track record moving programs from Discovery to Development (pharma/biotech).
- Deep small-molecule DMPK expertise; ADC/peptide/proximity-inducing experience is a plus.
- Familiar with IND submission requirements and regulatory interactions.
- Strong collaborative leadership; comfortable across biology and technology.
Technical Skills & Expertise
- In vitro/in vivo ADME and contemporary PK/PD modeling; experience supporting CNS exposure and/or restricting peripheral exposure.
- Human PK and efficacious dose prediction.
- Manage CROs for quality data and timely delivery; biotransformation/metabolic pathway knowledge.
Working Location & Compensation
- Hybrid office role (50% in office) in Salt Lake City or New York City. Base salary range: $284,900–$400,950; bonus, equity, and comprehensive benefits.