Group Manager, CMC Project Management
Arrowhead Pharmaceuticals
August 21, 2026
Remote friendly (Madison, WI)
United States
Operations
The Position
Group Manager, PDO responsible for end-to-end alignment of Arrowhead products from preclinical through commercial phases. Accountable for assigned projects and leads cross-functional CMC teams from drug substance process development through delivery of clinical kits. Oversees internal and external CMC activities to ensure alignment with program timelines, quality standards, and regulatory requirements. Manages direct reports and provides mentoring, performance management, and team development. Partner-facing point of contact for stakeholders and external partners, including primary contact for CMOs and CROs supporting development, analysis, manufacturing, packaging, and labeling.
Responsibilities
- Serve as primary point of contact for CMC projects; facilitate internal/external communication
- Maintain project status understanding and tailor communications
- Manage budget, timeline, quality, and deliverables for each project/vendor
- Escalate risks, drive scenario planning, and recommend actions to leadership
- Maintain/expand project tracking tools (e.g., Smartsheet, Excel, Power BI)
- Analyze metrics and prepare recommendations
- Interface with cross-functional teams (Chemistry, Engineering, Analytical, Quality)
- Track/manage/negotiate proposals; draft RFPs with technical SMEs and Legal
- Steer alignment across SMEs, Sourcing & Supplier Management, Legal, Finance on contracts and POs
- Track vendor invoices and coordinate payments with Finance
- Develop/maintain performance metrics for internal/external partners
- Lead meetings, vendor/partner visits, and calls; facilitate team consensus
- Support vendor management and CMC outsourcing budget development/review
- Coach/mentor direct reports; generate/maintain training materials; support onboarding
- Collaborate with Alliance Management on partnership goals
Requirements
- Bachelor’s degree in a scientific field (Chemistry, Chemical Engineering, Biochemistry, Biotechnology)
- 8 years increasing responsibility in pharma/CMO/CRO with direct report experience
- 5+ years in project management managing clients/partners/vendors
- Knowledge of GLP, GMP, and regulatory guidance for pharma manufacturing/testing
- Strong MS Office skills (Outlook, Excel, PowerPoint, Word)
- Excellent verbal/written communication; work effectively in matrix environments
- Highly motivated team player; detail-oriented, organized self-starter
Preferred
- Master’s degree in related science
- GLP or GMP lab/manufacturing experience
- Late-stage CMC drug development/commercialization experience
- Project Management Certification; ERP system experience
Group Manager, PDO responsible for end-to-end alignment of Arrowhead products from preclinical through commercial phases. Accountable for assigned projects and leads cross-functional CMC teams from drug substance process development through delivery of clinical kits. Oversees internal and external CMC activities to ensure alignment with program timelines, quality standards, and regulatory requirements. Manages direct reports and provides mentoring, performance management, and team development. Partner-facing point of contact for stakeholders and external partners, including primary contact for CMOs and CROs supporting development, analysis, manufacturing, packaging, and labeling.
Responsibilities
- Serve as primary point of contact for CMC projects; facilitate internal/external communication
- Maintain project status understanding and tailor communications
- Manage budget, timeline, quality, and deliverables for each project/vendor
- Escalate risks, drive scenario planning, and recommend actions to leadership
- Maintain/expand project tracking tools (e.g., Smartsheet, Excel, Power BI)
- Analyze metrics and prepare recommendations
- Interface with cross-functional teams (Chemistry, Engineering, Analytical, Quality)
- Track/manage/negotiate proposals; draft RFPs with technical SMEs and Legal
- Steer alignment across SMEs, Sourcing & Supplier Management, Legal, Finance on contracts and POs
- Track vendor invoices and coordinate payments with Finance
- Develop/maintain performance metrics for internal/external partners
- Lead meetings, vendor/partner visits, and calls; facilitate team consensus
- Support vendor management and CMC outsourcing budget development/review
- Coach/mentor direct reports; generate/maintain training materials; support onboarding
- Collaborate with Alliance Management on partnership goals
Requirements
- Bachelor’s degree in a scientific field (Chemistry, Chemical Engineering, Biochemistry, Biotechnology)
- 8 years increasing responsibility in pharma/CMO/CRO with direct report experience
- 5+ years in project management managing clients/partners/vendors
- Knowledge of GLP, GMP, and regulatory guidance for pharma manufacturing/testing
- Strong MS Office skills (Outlook, Excel, PowerPoint, Word)
- Excellent verbal/written communication; work effectively in matrix environments
- Highly motivated team player; detail-oriented, organized self-starter
Preferred
- Master’s degree in related science
- GLP or GMP lab/manufacturing experience
- Late-stage CMC drug development/commercialization experience
- Project Management Certification; ERP system experience