Global Therapeutic Research Lead - Small Molecule - Immunology

Role: Global Therapeutic Research Lead (G-TRL) responsible for driving research projects from discovery to clinical development within Takeda's Gastroenterology and Inflammation (GI DDU) focus. Main objectives include leading high-priority drug discovery programs, shaping early asset strategy, managing external partnerships, and ensuring alignment with organizational and therapeutic area strategies. Responsibilities involve overseeing target identification, hit-to-lead optimization, and preclinical development, with a strong emphasis on small molecule modalities and familiarity with biologics. The role requires mentoring global teams, fostering innovation, and representing Takeda externally to industry and academic partners. Qualifications: Ph.D., M.D., or D.V.M. with 10-12+ years industry experience in drug discovery, particularly in immunology/inflammation, with proven leadership in multi-project management and delivering compounds to the clinic. Deep expertise in target validation, medicinal chemistry, and AI/ML-driven discovery is expected. The position entails strategic input into portfolio decisions, stakeholder engagement, and representing research externally. Work setup is hybrid in Cambridge, MA, with a salary range of $212,000-$333,190 based on expertise and experience.