Global Health Economics & Outcomes Research (HEOR) Associate Director (HYBRID)

Role Summary

Global Health Economics & Outcomes Research (HEOR) Associate Director will shape and execute HEOR strategies that optimize the value proposition for Vertex’s CF and early pipeline assets through each stage of development, including launch and post-launch phases. The role reports to the Executive Director HEOR, CF and Early Pipeline and is based in Boston’s Seaport District (hybrid-eligible).

Responsibilities

• Leads execution of complex HEOR evidence generation studies, including prospective and retrospective observational studies, COA strategy, PRO measure development and validation, systematic literature reviews, cost-effectiveness analyses, budget impact models, and indirect treatment comparisons to support asset value.
• Effectively leads external research partners to ensure robust scientific methods are applied to study design and execution, and oversees study design, data analysis, and quality of evidence; manages projects to deliver on time and within budget.
• Collaborates with medical communications teams on publication strategy to disseminate HEOR evidence timely and with maximum impact.
• Partners with Global Pricing and Market Access to support development of product value proposition and co-lead global launch deliverables (e.g., global value dossier).

Skills

• Strong track record of publication in peer-reviewed journals
• Background in clinical outcome assessment (COA) measurement strategy; experience in PRO development/validation and qualitative research methodology
• Technical expertise in HEOR with ability to formulate and lead creative research projects; hands-on experience with prospective and site-based research
• Strong verbal and written communication skills, including ability to present complex concepts to diverse audiences
• Excellent project and people management skills to oversee vendors and internal teams, coordinating with cross-functional partners to meet timelines and budgets
• Ability to apply knowledge of the US healthcare system, global health technology appraisal requirements, and clinical development to identify evidence gaps and generate strategies
• Understanding of the regulatory environment of the pharmaceutical industry with a history of compliant and ethical conduct

Education

• Advanced degree (PhD, MD, Master's, MPH, or PharmD) in a relevant discipline
• Typically requires 8+ years of relevant experience in a Global HEOR role within a pharmaceutical/biotech setting, or equivalent