Global Development Product Lead (Sr Director)

Job Responsibilities
- Lead multiple (~1-3) cross-functional oncology product teams from pre-clinical candidate nomination (CAN) through Phase 1–2 clinical development and proof of concept (POC), then hand off to late-stage Oncology Development for post-POC development (typically Phase 3).
- Integrate end-to-end cross-functional molecule strategy and risk mitigation plan with functional experts; deliver data-driven milestones through risk identification and mitigation.
- Support clinical trials and early development asset and lead development program strategy across Pfizer Oncology; represent the program with the external clinical community.
- Develop clinical development plans from first-in-human to POC, including appropriate combinations and evaluation of predictive and pharmacodynamics biomarker plans.
- Provide clinical plan components and clinical expertise to project teams, including medical monitoring of clinical trials.
- Lead and execute strategic development for early development assets; drive integrated product plans aligned to future pivotal development and commercialization.
- Ensure timely execution and delivery of product milestones within budget.
- Communicate needs and recommendations to executive management and governance committees; ensure clear product presentations.
- Collaborate on co-development programs and shared global product strategy.
- Set objectives, prioritize tasks, and ensure adherence to plan and strategy.
- Proactively identify/resolves issues and develop contingency plans to manage risk.
- Oversee early development assets across an indication/group of indications (typically at least two clinical programs) and consult on multiple research projects.
- Oversee development across multifunctional teams (Product Team, Global Development Team, Study team).
- Oversee clinical protocols/amendments, investigator brochures, clinical study reports, statistical analysis plans, and regulatory documents.
- Lead and mentor early-stage clinical scientists in a matrix environment; provide regular cross-functional alignment across Pfizer Oncology leaders/surrogates.
- Oversee PK-guided dose escalation, early combination strategies, and innovations on all Oncology R&D first-in-human trials.
- Oversee evaluation of safety, pharmacology, and efficacy data.
- Oversee manuscripts, abstracts, presentations for scientific meetings and advisory boards.
- Conduct literature reviews and prepare summaries to support clinical development programs.
- Serve as a medical resource for design and interpretation of clinical and preclinical programs.
- Coordinate quarterly (and as needed) interactions with clinical trials networks and KOL advisory boards to implement feedback.
- Drive innovations in early clinical development and apply translational oncology and precision medicine approaches.
- Collaborate to translate early preclinical discovery into therapeutic candidates.
- Coordinate with business development for strategic external collaborations and new research projects/programs.

Qualifications / Skills
- MD or MD-PhD with 5+ years of industry experience (required).
- Oncology drug development experience and a track record in oncology clinical research/early phase development (preferred).
- Clinical oncology experience; board certification in oncology (preferred).
- Significant leadership experience in clinical, translational, or basic research related to biomedical sciences/drug development.
- Understanding of related disciplines (e.g., biostatistics, regulatory, pre-clinical pharmacology, pharmaceutical sciences).
- Demonstrated scientific productivity (publications, abstracts, etc.).
- Proven scientific writing and strong communication skills.
- Proven ability to lead and defend the clinical plan at governance meetings (essential).
- Ability to adapt to fast-paced, changing environments.
- Demonstrated leadership in cross-functional/matrixed teams; experience seeking and maintaining cross-functional alignment.
- Passion for helping patients with cancer and for the science of oncology.
- Proactive, strategic, data-driven decision-making.
- Ability to focus and motivate a matrix team with multiple stakeholders.
- Strong verbal, written, and presentation communication skills.
- Staff management and mentoring experience.
- Highly collaborative relationship-building skills with internal leadership, external partners, investigators, and medical professionals.
- Global perspective and ability to work effectively across cultures/geographies.