Global Development Product Lead (Executive Director)

Role Summary

Global Development Product Lead (Executive Director) oversees multiple cross-functional oncology product teams from pre-clinical candidate nomination through Phase 1-2 development and proof of concept, with potential handoff to late-stage development for post-POC progression. The role drives end-to-end molecule strategy, risk mitigation, and data-driven milestone delivery, while representing programs to the external clinical community.

Responsibilities

• Lead multiple cross-functional oncology product teams through early development stages and integrate end-to-end strategy to drive milestones
• Support clinical trials and development strategy for early assets, represent programs with external clinical community
• Develop clinical development plans from first-in-human to proof-of-concept, including biomarker plans
• Ensure cross-functional components, including clinical expertise, are provided to project teams and medical monitoring of trials
• Provide substantial support for CDP development and diligence for external innovation activities
• Lead enterprise-level cross-functional workstreams to accelerate R&D decision making
• Lead, develop and execute strategic development for early assets, driving integrated product plans with GPTs
• Ensure timely execution and delivery of milestones within budget
• Communicate with executive management and governance committees; deliver clear product presentations
• Collaborate with partners on co-development programs to deliver a shared global product strategy
• Set objectives, prioritize tasks, and ensure adherence to plans and strategy
• Manage risk by identifying issues and developing contingency plans
• Oversee development of early assets across indications, supporting multiple research projects
• Work across organization with multifunctional teams for early development asset development
• Oversee development and management of clinical protocols, investigator brochures, study reports, SAPs, and regulatory documents
• Provide leadership to early-stage clinical scientists in a matrix team environment
• Implement PK-guided dose escalation, early combination strategies, and innovations in first-in-human trials
• Oversee evaluation of safety, pharmacology, and efficacy data for early assets
• Oversee manuscripts, abstracts, and presentations for scientific meetings
• Conduct literature reviews and prepare summaries to support development programs
• Act as medical resource for design and interpretation of clinical and preclinical programs
• Coordinate regular interactions with clinical trials networks and KOL advisory boards
• Drive innovations in early clinical development and translational oncology approaches
• Collaborate with cross-functional leaders to translate early discovery into candidates
• Coordinate with business development to establish external collaborations
• Contribute to organizational excellence as a member of the OESD department and foster a transparent, collaborative team environment

Qualifications

• MD or MD-PhD with 10+ years of oncology drug development experience; track record in oncology clinical research, including early development (Preferred)
• Clinical oncology experience; board certification in oncology preferred
• Significant leadership experience in clinical, translational, or basic biomedical research related to drug development
• Understanding of biostatistics, regulatory, pre-clinical pharmacology, and pharmaceutical sciences
• Demonstrated scientific productivity (publications, abstracts)
• Proven scientific writing and strong communication skills
• Proven leadership abilities with capability to defend clinical plans at governance meetings
• Adaptability to a fast-paced, changing environment
• History of effective cross-functional leadership in a matrix organization
• Passion for oncology and patient impact; data-driven decision-making
• Strong mentoring, collaboration, and relationship-building skills with internal and external partners
• Global perspective with ability to collaborate across cultures and geographies

Skills

• Strategic development and portfolio governance
• Cross-functional team leadership and matrix management
• Clinical trial design, regulatory documentation, and translational medicine
• Data-driven decision making and risk management
• Effective communication with executive stakeholders
• Collaborative partnering and external collaboration management

Education

• MD or MD-PhD required

Additional Requirements

• Hybrid role requiring residence within commuting distance and on-site presence approximately 2.5 days per week