Global Development Product Lead (Executive Director)

Role Summary

Global Development Product Lead (Executive Director) leads multiple cross-functional oncology product teams from pre-clinical candidate nomination through Phase 1-2 clinical development and proof of concept, with potential handoff to late-stage development. The role drives end-to-end cross-functional strategy, coordinates milestone-driven plans, and represents the program to the external clinical community. It includes developing clinical development plans, managing cross-functional inputs, and leading enterprise-level workstreams to accelerate R&D decision making.

Responsibilities

• Leads multiple (~2-4) cross-functional oncology product teams from pre-clinical candidate nomination through Phase 1-2 clinical development and proof of concept, with potential handoff to late-stage development.
• Drives integration of an end-to-end cross-functional molecule strategy and risk mitigation plan; ensures delivery of data-driven milestones through risk identification and mitigation.
• Supports clinical trials and development strategy for early development assets and lead programs; represents the program with the external clinical community.
• Develops clinical development plans from first-in-human trials to proof-of-concept, including assessment of combinations and biomarker plans.
• Ensures cross-functional components of product plans include clinical expertise and medical monitoring of trials.
• Provides substantial support of CDP development and diligence for external innovation activities.
• Leads enterprise-level cross-functional workstreams to accelerate R&D decision making.
• Lead, develop and execute strategic development for early development assets; drive an integrated product plan with Global Product Teams to address technical uncertainties and align with future pivotal development and commercialization.
• Ensure timely execution and delivery of product milestones within budget.
• Communicate with executive management and governance committees to address program needs and provide recommendations; ensure clear and effective product presentations and communications.
• Collaborate with partners on co-development programs to deliver a shared global product strategy when applicable.
• Lead the team to set objectives, prioritize tasks, and ensure adherence to the plan and strategy.
• Manage risk by proactively identifying and resolving issues and developing contingency plans.
• Oversee early development assets’ development across specific indications or groups of indications; typically work on multiple clinical programs and provide consultation on research projects.
• Work across the organization on multifunctional teams responsible for developing early development assets (including Product Team, Global Development Team, Study team).
• Oversee development and management of clinical protocols and amendments, investigator brochures, clinical study reports, statistical analysis plans, and regulatory documents.
• Provide leadership to early stage clinical scientists within a matrix team environment with clinicians, statisticians, pharmacologists, translational biologists and regulatory specialists; engage with Oncology group leaders across functions to align targets and priorities.
• Implement PK-guided dose escalation, early combination strategies, and innovations on first-in-human trials with cross-functional input.
• Oversee evaluation of safety, pharmacology, and efficacy data from studies for early development assets.
• Oversee manuscripts, abstracts, and presentations for scientific meetings and advisory boards; conduct literature reviews to support programs.
• Act as a medical resource for design and interpretation of clinical and preclinical programs; coordinate regular interactions with clinical trials networks and KOL advisory boards to consider feedback.
• Drive innovations in early clinical development and translational oncology/precision medicine approaches.
• Collaborate with cross-functional leaders to translate early preclinical discovery into therapeutic candidates.
• Coordinate with business development to establish external collaborations and foster new research projects.
• Contribute to organizational excellence as a member of the OESD department; foster a positive team environment emphasizing trust, transparency, and alignment on goals.

Qualifications

• MD or MD-PhD with 10+ years of industry experience in oncology drug development; track record in oncology clinical research including early-phase development.
• Clinical oncology experience; board certification in oncology preferred.
• Significant leadership experience in clinical, translational, or basic biomedical research related to drug development.
• Understanding of biostatistics, regulatory, pre-clinical pharmacology, and pharmaceutical sciences.
• Demonstrated scientific productivity (publications, abstracts, etc.).
• Proven scientific writing and strong communication skills.
• Proven leadership skills with ability to defend the clinical plan at governance meetings; capacity to adapt to a fast-paced environment.
• History of effective leadership in cross-functional/matrixed teams; experience managing direct reports and aligning cross-functional leaders.
• Passion for helping patients with cancer and for oncology science; proactive, strategic thinker with data-driven decision-making skills.
• Ability to motivate a team in a matrix organization with multiple stakeholders; strong verbal, written, and presentation skills.
• Effective mentoring skills; highly collaborative with strong relationship-building abilities with internal leadership, external partners, and investigators.
• Strong leadership presence with the ability to influence at enterprise level; team player who works well as a leader and contributor.
• Global perspective and ability to work with colleagues from diverse cultures and geographies.

Additional Requirements

• Hybrid role requiring you to live within commuting distance and work on-site an average of 2.5 days per week.