Global Development Lead, Internal Medicine, Sr. Director (non-MD)
Pfizer
August 10, 2026
Remote friendly (Cambridge, MA)
United States
Clinical Research and Development
Responsibilities
- Lead cross-functional Clinical Development Team to design, execute, and interpret studies for worldwide regulatory submissions.
- Create and gain endorsement of the Clinical Development Plan and associated protocol design documents.
- Lead pediatric investigation plan/study plan and protocol design; ensure trial feasibility and optimized operations.
- Provide product/program input to Target Product Profile(s); develop clinical development enabling strategies (digital/innovation, patient engagement).
- Partner with trial clinicians on governance reviews; provide therapy area/indication expertise (CRF design, signal interpretation, adverse event context).
- Contribute to trial-level statistical analysis plan, TLFs/table-listings-figures, and database release.
- Develop submission deliverables (IAP, IARP, submission TLFs) including SCE and SCS; review/approve safety narrative plan; support label development/maintenance.
- Support regulatory submissions/disclosures (DSUR, PBRER) and product defense.
- Engage external stakeholders (ad boards, steering committees, DMC, adjudication committees, patients/advocates).
- Ensure compliance with internal SOPs and external regulatory standards.
Qualifications (Basic)
- PhD/PharmD.
- 8+ years clinical research & development; Phase 1–3 and translational medicine experience.
- Background in chronic weight management, endocrinology, or internal medicine.
- Extensive knowledge of clinical development, ICH/GCP, global/regional regulation, adverse event management.
Skills/Competencies
- Clinical/pharmaceutical development excellence; strong leadership/influencing in matrixed teams; conflict management; accountability; change agility.
Compensation/Benefits (if hired)
- Base salary: $214,900–$358,100; bonus target 22.5%; eligible for share-based long-term incentives; 401(k) with matching; paid vacation/holidays/personal days; caregiver/parental and medical leave; medical/dental/vision.
Work/Travel
- Up to 30% travel; hybrid role on-site ~2.5 days/week.
- Lead cross-functional Clinical Development Team to design, execute, and interpret studies for worldwide regulatory submissions.
- Create and gain endorsement of the Clinical Development Plan and associated protocol design documents.
- Lead pediatric investigation plan/study plan and protocol design; ensure trial feasibility and optimized operations.
- Provide product/program input to Target Product Profile(s); develop clinical development enabling strategies (digital/innovation, patient engagement).
- Partner with trial clinicians on governance reviews; provide therapy area/indication expertise (CRF design, signal interpretation, adverse event context).
- Contribute to trial-level statistical analysis plan, TLFs/table-listings-figures, and database release.
- Develop submission deliverables (IAP, IARP, submission TLFs) including SCE and SCS; review/approve safety narrative plan; support label development/maintenance.
- Support regulatory submissions/disclosures (DSUR, PBRER) and product defense.
- Engage external stakeholders (ad boards, steering committees, DMC, adjudication committees, patients/advocates).
- Ensure compliance with internal SOPs and external regulatory standards.
Qualifications (Basic)
- PhD/PharmD.
- 8+ years clinical research & development; Phase 1–3 and translational medicine experience.
- Background in chronic weight management, endocrinology, or internal medicine.
- Extensive knowledge of clinical development, ICH/GCP, global/regional regulation, adverse event management.
Skills/Competencies
- Clinical/pharmaceutical development excellence; strong leadership/influencing in matrixed teams; conflict management; accountability; change agility.
Compensation/Benefits (if hired)
- Base salary: $214,900–$358,100; bonus target 22.5%; eligible for share-based long-term incentives; 401(k) with matching; paid vacation/holidays/personal days; caregiver/parental and medical leave; medical/dental/vision.
Work/Travel
- Up to 30% travel; hybrid role on-site ~2.5 days/week.