Global Development Lead, Internal Medicine (MD, Sr. Director)
Pfizer
August 13, 2026
Remote friendly (Cambridge, MA)
United States
Clinical Research and Development
Responsibilities:
- Lead cross-functional clinical development for assigned Internal Medicine asset(s), serving as clinical point of accountability.
- Create and obtain endorsement for the Clinical Development Plan and protocol design documents; partner through study lifecycle and with external partners (Partner of Choice model).
- Lead/oversee trial design, execution, reporting, governance reviews, and clinical data interpretation (including CRF design, signal interpretation, adverse event contextualization).
- Develop clinical development enabling strategies (digital/innovation and patient engagement).
- Provide therapy-area expertise; support statistical analysis plans, TLFs/table-listings-figures, and database release (with Statistics/Programming).
- Own submission-level deliverables (IAP/IARP, submission TLFs, SCE, SCS) and safety narrative plan review/approval; support DSUR and PBRER disclosures and product defense.
- Support regulatory and label development/maintenance; engage external stakeholders (ad boards, steering committees, DMC, adjudication committees, patients).
- Ensure compliance with internal SOPs and external regulatory standards.
Qualifications:
- MD or DO.
- Endocrinologist or internal medicine physician with cardiometabolic late-stage development experience, including Type 2 diabetes.
- 8+ years clinical R&D experience with success in academia and/or biopharma.
- Extensive knowledge of clinical development, global/regional regulation, ICH/GCP, and adverse event management.
- Demonstrated clinical/administrative/project management and leadership; ability to influence in a matrix environment.
Travel/Location:
- Up to 30% travel.
- Hybrid role: live within commuting distance; on-site ~2.5 days/week.
- Relocation support available.
Benefits (if eligible):
- Global Performance Plan bonus target 25% of base salary; share-based long-term incentive; medical/dental/vision, 401(k) matching and retirement savings contribution, paid time off, and caregiver/parental leave.
- Lead cross-functional clinical development for assigned Internal Medicine asset(s), serving as clinical point of accountability.
- Create and obtain endorsement for the Clinical Development Plan and protocol design documents; partner through study lifecycle and with external partners (Partner of Choice model).
- Lead/oversee trial design, execution, reporting, governance reviews, and clinical data interpretation (including CRF design, signal interpretation, adverse event contextualization).
- Develop clinical development enabling strategies (digital/innovation and patient engagement).
- Provide therapy-area expertise; support statistical analysis plans, TLFs/table-listings-figures, and database release (with Statistics/Programming).
- Own submission-level deliverables (IAP/IARP, submission TLFs, SCE, SCS) and safety narrative plan review/approval; support DSUR and PBRER disclosures and product defense.
- Support regulatory and label development/maintenance; engage external stakeholders (ad boards, steering committees, DMC, adjudication committees, patients).
- Ensure compliance with internal SOPs and external regulatory standards.
Qualifications:
- MD or DO.
- Endocrinologist or internal medicine physician with cardiometabolic late-stage development experience, including Type 2 diabetes.
- 8+ years clinical R&D experience with success in academia and/or biopharma.
- Extensive knowledge of clinical development, global/regional regulation, ICH/GCP, and adverse event management.
- Demonstrated clinical/administrative/project management and leadership; ability to influence in a matrix environment.
Travel/Location:
- Up to 30% travel.
- Hybrid role: live within commuting distance; on-site ~2.5 days/week.
- Relocation support available.
Benefits (if eligible):
- Global Performance Plan bonus target 25% of base salary; share-based long-term incentive; medical/dental/vision, 401(k) matching and retirement savings contribution, paid time off, and caregiver/parental leave.