Global Development Lead, Internal Medicine (MD, Sr. Director)
Pfizer
August 13, 2026
Remote friendly (Lake Forest, IL)
United States
Clinical Research and Development
Role Summary
- Lead clinical development for assigned Internal Medicine asset(s) as the single clinical point of accountability.
- Lead cross-functional Clinical Development Team (clinical, clinical pharmacology, statistics, safety, commercial, patient access, operations) to design, execute, and interpret studies supporting worldwide regulatory submissions.
- Create and secure endorsement for the Clinical Development Plan and associated protocol design documents.
- Serve as an internal subject matter expert in therapeutic area and clinical drug development; may support Obesity portfolio clinical leadership.
Responsibilities
- Negotiate tradeoffs, milestones; ensure delivery of clinical program within timelines and budget.
- Build global clinical development plans (including China/Japan); create pediatric investigation/study plans and protocol design documents.
- Provide input to target product profile(s); governance and clinical strategy input to trial clinicians.
- Provide therapy area expertise (CRF design, signal interpretation, adverse event contextualization).
- Contribute to statistical analysis plan (tables/listings/figures; database release) with statistics/programming.
- Develop submission deliverables (IAP/IARP/TLFs) including SCE/SCS; review/approve submission safety narrative plan.
- Support label development/maintenance; interpret and communicate clinical data.
- Engage external stakeholders (Ad boards, Steering Committees, DMC, adjudication committees, patients/advocates) to inform clinical strategy and PDD development.
- Provide regulatory submission support (DSUR/PBRER) including disclosure deliverables and product defense; ensure compliance with SOPs and regulatory standards.
Basic Qualifications
- MD or DO.
- Endocrinologist or internal medicine physician with cardiometabolic late-stage development experience including type 2 diabetes.
- 8+ years clinical research & development experience (academia and/or biopharma).
- Extensive knowledge of clinical development, global/regional regulation, ICH/GCP, adverse event management.
Skills/Competencies (required)
- Clinical/medical, administrative, and project management; strong verbal/written communication.
- Experience managing/training large clinical development teams; matrix leadership and influencing.
Travel/Environment
- Up to 30% travel.
- Hybrid: live within commuting distance; on-site ~2.5 days/week.
Benefits/Compensation
- Eligible for Pfizer Global Performance Plan bonus target 25% and long-term incentive program; comprehensive benefits (401(k) match, vacation/leave, medical/dental/vision).
- Lead clinical development for assigned Internal Medicine asset(s) as the single clinical point of accountability.
- Lead cross-functional Clinical Development Team (clinical, clinical pharmacology, statistics, safety, commercial, patient access, operations) to design, execute, and interpret studies supporting worldwide regulatory submissions.
- Create and secure endorsement for the Clinical Development Plan and associated protocol design documents.
- Serve as an internal subject matter expert in therapeutic area and clinical drug development; may support Obesity portfolio clinical leadership.
Responsibilities
- Negotiate tradeoffs, milestones; ensure delivery of clinical program within timelines and budget.
- Build global clinical development plans (including China/Japan); create pediatric investigation/study plans and protocol design documents.
- Provide input to target product profile(s); governance and clinical strategy input to trial clinicians.
- Provide therapy area expertise (CRF design, signal interpretation, adverse event contextualization).
- Contribute to statistical analysis plan (tables/listings/figures; database release) with statistics/programming.
- Develop submission deliverables (IAP/IARP/TLFs) including SCE/SCS; review/approve submission safety narrative plan.
- Support label development/maintenance; interpret and communicate clinical data.
- Engage external stakeholders (Ad boards, Steering Committees, DMC, adjudication committees, patients/advocates) to inform clinical strategy and PDD development.
- Provide regulatory submission support (DSUR/PBRER) including disclosure deliverables and product defense; ensure compliance with SOPs and regulatory standards.
Basic Qualifications
- MD or DO.
- Endocrinologist or internal medicine physician with cardiometabolic late-stage development experience including type 2 diabetes.
- 8+ years clinical research & development experience (academia and/or biopharma).
- Extensive knowledge of clinical development, global/regional regulation, ICH/GCP, adverse event management.
Skills/Competencies (required)
- Clinical/medical, administrative, and project management; strong verbal/written communication.
- Experience managing/training large clinical development teams; matrix leadership and influencing.
Travel/Environment
- Up to 30% travel.
- Hybrid: live within commuting distance; on-site ~2.5 days/week.
Benefits/Compensation
- Eligible for Pfizer Global Performance Plan bonus target 25% and long-term incentive program; comprehensive benefits (401(k) match, vacation/leave, medical/dental/vision).