Global Development Lead, Early Clinical Development, Internal Medicine
Pfizer
20 days ago
Remote friendly (Pennsylvania, United States)
United States
Clinical Research and Development
Role Responsibilities:
- Lead creation of the clinical development plan from pre-clinical stages through proof of concept.
- Guide clinical teams to translate clinical research plans into efficiently delivered studies; conceive novel study designs optimized for operational effectiveness.
- Oversee design and execution of clinical research studies (methodology, clinical pharmacology, biomarkers, proof of mechanism, proof of concept, medical device, etc.).
- Accountable for development of clinical documents (protocol, clinical report, and regulatory submission components); provide final sign-off.
- Serve as Medically Qualified Individual (MQI) reviewing trial data for safety signal identification and tracking.
- Provide input to operational strategy and feasibility with Clinical Development Scientists and Clinical Operations.
- Establish relationships with key clinical experts/sites to advise site selection.
- Contribute medical/scientific expertise to target progression from synthesis to human testing.
- Manage dynamic portfolios and multiple programs in parallel.
- Contribute to technical and protocol review committees across the portfolio.
- May hold concomitant roles (Translational Medicine Lead; Research Project Leader).
Qualifications:
- MD or MD/PhD with relevant postgraduate clinical training.
- Completion of an accredited cardiology fellowship strongly preferred.
- Minimum 5 years industry drug development or relevant biomedical research experience.
- Proven scientific scholarship; strong drug development knowledge with emphasis on early clinical development.
- Deep knowledge of integrated metabolism biology and metabolic diseases (cardiovascular/cardiometabolic disorders, obesity, diabetes, cachexia).
- Ability to design, initiate, and conduct effective clinical studies and integrate into a cohesive strategy.
- Strong understanding of relevant disease/technical complexities; regulatory requirements plus GCP and ICH guidelines.
- Ability to review emerging data and proactively ensure quality.
- Skilled communicator and team leader; manage teams across disciplines/geographies.
Preferred Qualifications:
- Board eligibility/certification in Cardiovascular Disease or related subspecialty; active medical license.
- Matrix management of project teams and/or as an RPL (teams ~3–20).
Skills/Leadership:
- Ability to influence, collaborate, develop/coach others, and oversee colleagues to achieve meaningful outcomes.
Benefits/Work Conditions (explicitly stated):
- Up to 30% travel; relocation support available; hybrid work (on-site ~2.5 days/week).
Compensation (explicitly stated):
- Base salary $274,500–$457,500; bonus target 25% plus share-based long-term incentives; 401(k) matching and additional retirement contribution; paid time off and health benefits.
- Lead creation of the clinical development plan from pre-clinical stages through proof of concept.
- Guide clinical teams to translate clinical research plans into efficiently delivered studies; conceive novel study designs optimized for operational effectiveness.
- Oversee design and execution of clinical research studies (methodology, clinical pharmacology, biomarkers, proof of mechanism, proof of concept, medical device, etc.).
- Accountable for development of clinical documents (protocol, clinical report, and regulatory submission components); provide final sign-off.
- Serve as Medically Qualified Individual (MQI) reviewing trial data for safety signal identification and tracking.
- Provide input to operational strategy and feasibility with Clinical Development Scientists and Clinical Operations.
- Establish relationships with key clinical experts/sites to advise site selection.
- Contribute medical/scientific expertise to target progression from synthesis to human testing.
- Manage dynamic portfolios and multiple programs in parallel.
- Contribute to technical and protocol review committees across the portfolio.
- May hold concomitant roles (Translational Medicine Lead; Research Project Leader).
Qualifications:
- MD or MD/PhD with relevant postgraduate clinical training.
- Completion of an accredited cardiology fellowship strongly preferred.
- Minimum 5 years industry drug development or relevant biomedical research experience.
- Proven scientific scholarship; strong drug development knowledge with emphasis on early clinical development.
- Deep knowledge of integrated metabolism biology and metabolic diseases (cardiovascular/cardiometabolic disorders, obesity, diabetes, cachexia).
- Ability to design, initiate, and conduct effective clinical studies and integrate into a cohesive strategy.
- Strong understanding of relevant disease/technical complexities; regulatory requirements plus GCP and ICH guidelines.
- Ability to review emerging data and proactively ensure quality.
- Skilled communicator and team leader; manage teams across disciplines/geographies.
Preferred Qualifications:
- Board eligibility/certification in Cardiovascular Disease or related subspecialty; active medical license.
- Matrix management of project teams and/or as an RPL (teams ~3–20).
Skills/Leadership:
- Ability to influence, collaborate, develop/coach others, and oversee colleagues to achieve meaningful outcomes.
Benefits/Work Conditions (explicitly stated):
- Up to 30% travel; relocation support available; hybrid work (on-site ~2.5 days/week).
Compensation (explicitly stated):
- Base salary $274,500–$457,500; bonus target 25% plus share-based long-term incentives; 401(k) matching and additional retirement contribution; paid time off and health benefits.