Gene Editing Research Scientist

Job Description About Vertex: At Vertex, we are relentless in our pursuit of transformative medicines to address the most serious diseases. Our team is dedicated to innovation, collaboration, and improving the lives of patients worldwide. Join us in our mission to create a healthier future. Position Summary: We are seeking a highly motivated and innovative Gene Editing Research Scientist to join our Gene Editing and Delivery team within the CGT department. In this role, you will be responsible for conceptually outlining studies, designing, and executing focused research projects or a series of complex experimental procedures. This includes the design, development, and testing of CRISPR-Cas gene editing tools in cellular models of disease. The ideal candidate will have the ability to design alternative approaches to achieve desired outcomes and will stay current on the latest scientific literature relevant to scientific methodologies and technical expertise. This position offers an exciting opportunity to contribute to cutting-edge research in gene editing and delivery technologies, driving transformative advancements in addressing unmet medical needs. Key Responsibilities: Design and Execute Complex Experiments: Develop and conduct molecular biology, cell culture, and genomic analysis to evaluate gene editing outcomes for optimization and advancement of gene editing and delivery technologies. Data Analysis and Interpretation: Systematically collate and interpret experimental data, synthesizing results into cohesive conclusions or actionable recommendations to guide project decisions and new research activities. Advanced Troubleshooting: Perform advanced experimental troubleshooting to address technical challenges and ensure the success of research projects. Incorporate Scientific Insights: Regularly review and integrate relevant scientific literature and emerging insights into ongoing research activities to maintain cutting-edge methodologies. Innovative Research Approaches: Explore the feasibility of applying new scientific principles or validate novel experimental approaches and technologies to achieve project objectives. Knowledge Dissemination: Prepare and deliver detailed study presentations, sharing experimental conclusions and insights at internal group, department, or project team research meetings. Intellectual Property and Publications: Contribute to the preparation of patents and/or scientific publications to document and share research findings. Cross-functional collaboration: Collaborate with cross-functional teams, including computational sciences and preclinical development, to advance therapeutic projects. Compliance: Ensure compliance with all regulatory and safety guidelines in the laboratory. Additional Responsibilities: Perform other duties as assigned to support the team and organizational goals. Qualifications: Required Education Level: Ph.D. (or equivalent degree) in molecular and cell biology, or related disciplines and 0-3 years of relevant post-doctoral employment experience, or Master’s degree (or equivalent degree) in molecular and cell biology, or related disciplines and 3+ years of relevant employment experience, or Bachelor’s Degree (or equivalent degree) in molecular and cell biology, or related disciplines and 6+ years of relevant employment experience Required Experience: Demonstrated hands-on experience with primary and immortalized cell culture, including cellular differentiation techniques. Practical expertise in gene editing and delivery technologies, such as CRISPR/Cas9, lipid nanoparticle (LNP) systems, and viral-based delivery methods. Proficiency in performing and analyzing advanced analytical assays, including high-content imaging and flow cytometry. Hands-on experience with molecular biology techniques, including Western blotting, genomic DNA (gDNA) and RNA extraction, quantitative PCR (qPCR), and Nanostring technologies. Strong analytical and problem-solving skills with the ability to interpret and synthesize complex experimental data. Excellent communication and collaboration skills to effectively contribute to a multidisciplinary team environment. Preferred Knowledge/Skills: Experience with high-throughput screening and automation. Experience with in vitro disease modeling using organoids or 3D engineered tissues Knowledge of regulatory requirements for gene editing in therapeutic applications. Pay Range: $108,000 - $162,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.