Executive Medical Director, Clinical Development- Immunology
Vertex Pharmaceuticals
August 29, 2026
Remote friendly (Boston, MA)
United States
Clinical Research and Development
Executive Medical Director, Clinical Development — Physician-Scientist (Immunology)
Key Duties And Responsibilities
- Requires comprehensive understanding of the drug development process from Phase 1 to Phase 4.
- Provide project team leadership to oversee clinical development program design and implementation.
- Plan and execute global clinical development activities (e.g., data monitoring committees, steering committees, investigator meetings).
- Represent the clinical development team at cross-functional meetings.
- Develop study protocols; review Investigator Brochures.
- Review and evaluate study subject exemptions.
- Oversee medical monitoring of clinical studies; assist medical monitors in evaluating adverse events and safety profiles.
- Participate in data reviews.
- Contribute to briefing books and preparation for regulatory interactions.
- Interface with international regulatory authorities to support development objectives.
- Ensure compliance with applicable standards (e.g., GCP, ICH, and Vertex SOPs).
- People management; may include financial accountabilities and HR responsibilities for assigned staff.
Knowledge And Skills
- Immunology or rheumatology authority; global regulatory agency experience (EMA, Health Canada, TGA, PMDA, CDE).
- Working knowledge of biostatistics, data management, clinical operations, and clinical pharmacology.
- Experience filing/defending US INDs/NDAs (or equivalents).
- Ability to work in fast-paced/ambiguous environments; collaborate in matrix settings; independent problem-solving.
- Excellent computer skills (including familiarity with AI-based large language models), and strong oral/written communication and leadership.
Education And Experience
- 15 years pharmaceutical industry experience (clinical trial/development oversight) and 7 years people management experience.
- Immunology and/or rheumatology expertise; board certification/eligibility.
Pay Range
- $320,000 - $480,000
Role is eligible for an annual bonus and annual equity awards.
Key Duties And Responsibilities
- Requires comprehensive understanding of the drug development process from Phase 1 to Phase 4.
- Provide project team leadership to oversee clinical development program design and implementation.
- Plan and execute global clinical development activities (e.g., data monitoring committees, steering committees, investigator meetings).
- Represent the clinical development team at cross-functional meetings.
- Develop study protocols; review Investigator Brochures.
- Review and evaluate study subject exemptions.
- Oversee medical monitoring of clinical studies; assist medical monitors in evaluating adverse events and safety profiles.
- Participate in data reviews.
- Contribute to briefing books and preparation for regulatory interactions.
- Interface with international regulatory authorities to support development objectives.
- Ensure compliance with applicable standards (e.g., GCP, ICH, and Vertex SOPs).
- People management; may include financial accountabilities and HR responsibilities for assigned staff.
Knowledge And Skills
- Immunology or rheumatology authority; global regulatory agency experience (EMA, Health Canada, TGA, PMDA, CDE).
- Working knowledge of biostatistics, data management, clinical operations, and clinical pharmacology.
- Experience filing/defending US INDs/NDAs (or equivalents).
- Ability to work in fast-paced/ambiguous environments; collaborate in matrix settings; independent problem-solving.
- Excellent computer skills (including familiarity with AI-based large language models), and strong oral/written communication and leadership.
Education And Experience
- 15 years pharmaceutical industry experience (clinical trial/development oversight) and 7 years people management experience.
- Immunology and/or rheumatology expertise; board certification/eligibility.
Pay Range
- $320,000 - $480,000
Role is eligible for an annual bonus and annual equity awards.