Executive Director of Early Commercial & Business Development

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You are an experienced leader who is intellectually curious and can bring new ideas and perspectives to our growing organization. You follow up and follow through, connecting problems with solutions with efficiency. You are proactive and have a demonstrated track record of driving cross-functional planning for multiple programs. You thrive in a collaborative environment, with strong interpersonal skills to effectively build working relationships internally and externally. 

The Opportunity

We are seeking a dynamic and experienced Executive Director of Early Commercial and Business Development to lead the transition to commercial readiness for our rare disease pipeline. This pivotal role combines commercial strategy, market planning, and partnership development, supporting the launch of therapies that will shape the future of treatment. The ideal candidate will have a strong background in both commercial and transactional execution within the biotechnology or pharmaceutical industry and be passionate about translating science into approved and accessible medicines.

You will report directly to the President and COO (Nathan Dowden - https://www.linkedin.com/in/nathan-dowden-1ba07b2/) and partner closely with all the functions of our growing organization.

Responsibilities

Early Commercial Strategy:

• Develop and implement commercial launch strategies for our lead neuromuscular disease programs in clinical development.
• Build comprehensive launch plans working closely with related functions to ensure operational effectiveness, financial viability, and seamless execution.
• Develop commercial execution roadmap and support the creation of an evolved organization structure.
• Leverage global market assessments, competitive landscape analyses, evolving regulatory requirements, and pricing/reimbursement evaluations to guide decision-making.

Business Development:

• Identify, evaluate, and execute partnership opportunities, including licensing, collaborations, and acquisitions, to enhance the company’s strategic goals.
• Cultivate and maintain relationships with key external stakeholders, including biopharma companies, investors, and academic collaborators.
• Lead the development of deal architecture and terms, and support negotiations of term sheets and agreements with potential partners in collaboration with business development, alliance management, legal, and finance.
• Support due diligence and negotiations, ensuring alignment with the company’s mission and objectives.

Cross-Functional Leadership:

• Collaborate with the program management, research, regulatory, clinical, manufacturing, quality, advocacy, investor relations and operations teams to integrate go-to-market strategies and strategic partnerships.
• Provide input to guide cross-functional program investment prioritization and resource allocation.
• Represent the company at industry conferences and advisory boards as needed.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

•    Ph.D., MD, and/or MBA required, with a focus in life sciences, healthcare, or business preferred.
•    15+ years post-education in biotechnology or pharmaceutical industries, with a focus on rare diseases, oncology, or Immunology & Inflammation.
•    Proven track record of leading early commercial strategy, launch planning, and operational implementation.
•    Experience developing a commercial organization and participating in launch rollout.
•    Experience leading business development activities and partner engagement.
•    Strong strategic planning and analytical skills.
•    Exceptional communication, negotiation, and leadership abilities.
•    Deep understanding of the biotechnology landscape, including rare disease market dynamics and competitive intelligence.

This role will align to our hybrid working model, with an expectation of 2 days per week on site in our Boston, MA office.

The Perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.