Executive Director - Head of Peptide Macrocycles Medicinal Chemistry

Role: Executive Director - Head of Peptide Macrocycles Medicinal Chemistry, leading discovery, optimization, and development of oral macrocyclic drugs. Responsibilities: formulate and execute strategic direction for macrocycle programs; oversee medicinal chemistry efforts using peptide chemistry and library-based screening technologies; mentor junior scientists; collaborate cross-functionally with ADME, safety, and PK/PD teams; drive programs from hit identification to candidate nomination and clinic progression. Requirements: PhD in chemistry, synthetic chemistry, or peptide chemistry; extensive experience in oral macrocycle drug discovery, with a proven track record of advancing molecules into clinical testing; deep expertise in macrocyclic peptides, library screening technologies (e.g., mRNA display, solution-phase, OBOC), and structure-guided optimization. Preferred: familiarity with computational/AI/machine learning tools in drug development; experience in peptide or protein therapeutics clinical success. HighValue: oral macrocyclic peptides, drug discovery and lead optimization, candidate progression to clinic, cross-functional collaboration, strategic leadership, team development. WorkSetup: onsite Pasadena, CA; some domestic and international travel expected.