Executive Director, Global Program Leader
Legend Biotech
August 20, 2026
Remote friendly (Somerset, NJ)
United States
Clinical Research and Development
Role Overview
Executive Director, Global Program Leader (GPL) is responsible for overall development, execution, and governance of Legend Biotech’s in vivo CAR-T programs.
Key Responsibilities
- Lead strategy and execution for assigned in vivo CAR-T programs across the development lifecycle.
- Develop and maintain integrated global development plans across scientific, clinical, regulatory, manufacturing, and commercial objectives.
- Accountable for program success, deliverables, timelines, budgets, and milestones.
- Drive portfolio decision-making (benefit-risk, competitive landscape, development options, investment priorities).
- Lead global clinical development and registration strategy.
- Partner with Clinical Development and Regulatory Affairs to design efficient pathways to proof-of-concept, pivotal development, and global approvals.
- Guide regulatory interactions and health authority milestones; ensure readiness for INDs, CTAs, BLA/MAA, and lifecycle management.
- Chair Global Program Teams; foster cross-functional collaboration (R&D, Translational, Clinical, Regulatory, Biometrics, CMC, Quality, Manufacturing, Commercial, Finance, Business Development).
- Establish governance, present strategies/risks to leadership, and manage risks/contingencies.
- Represent the company with external partners and support business development assessments.
- Mentor teams and build a patient-focused program culture.
Requirements
- 10+ years biotech/pharma drug development experience.
- 5+ years leading complex global development programs.
- Proven success advancing biologics/cell/gene therapies through clinical development.
- Experience leading cross-functional teams in a matrix environment.
- Experience with global regulatory interactions and major submissions.
- Oncology/immunology/cell therapy/gene therapy/in vivo genetic medicines strongly preferred.
Benefits
- Base pay range: $256,073–$336,097 USD; performance-based bonus and/or equity; medical/dental/vision; 401(k) match; 8 weeks paid parental leave after 3 months; paid time off (vacation, personal, sick, floating holidays, 11 company holidays; plus other voluntary benefits).
Work Authorization & Employment Eligibility
- Must be authorized to work in the United States; E-Verify and Form I-9 required if hired.
Executive Director, Global Program Leader (GPL) is responsible for overall development, execution, and governance of Legend Biotech’s in vivo CAR-T programs.
Key Responsibilities
- Lead strategy and execution for assigned in vivo CAR-T programs across the development lifecycle.
- Develop and maintain integrated global development plans across scientific, clinical, regulatory, manufacturing, and commercial objectives.
- Accountable for program success, deliverables, timelines, budgets, and milestones.
- Drive portfolio decision-making (benefit-risk, competitive landscape, development options, investment priorities).
- Lead global clinical development and registration strategy.
- Partner with Clinical Development and Regulatory Affairs to design efficient pathways to proof-of-concept, pivotal development, and global approvals.
- Guide regulatory interactions and health authority milestones; ensure readiness for INDs, CTAs, BLA/MAA, and lifecycle management.
- Chair Global Program Teams; foster cross-functional collaboration (R&D, Translational, Clinical, Regulatory, Biometrics, CMC, Quality, Manufacturing, Commercial, Finance, Business Development).
- Establish governance, present strategies/risks to leadership, and manage risks/contingencies.
- Represent the company with external partners and support business development assessments.
- Mentor teams and build a patient-focused program culture.
Requirements
- 10+ years biotech/pharma drug development experience.
- 5+ years leading complex global development programs.
- Proven success advancing biologics/cell/gene therapies through clinical development.
- Experience leading cross-functional teams in a matrix environment.
- Experience with global regulatory interactions and major submissions.
- Oncology/immunology/cell therapy/gene therapy/in vivo genetic medicines strongly preferred.
Benefits
- Base pay range: $256,073–$336,097 USD; performance-based bonus and/or equity; medical/dental/vision; 401(k) match; 8 weeks paid parental leave after 3 months; paid time off (vacation, personal, sick, floating holidays, 11 company holidays; plus other voluntary benefits).
Work Authorization & Employment Eligibility
- Must be authorized to work in the United States; E-Verify and Form I-9 required if hired.