Executive Director, Biotherapeutics DMPK
Vertex Pharmaceuticals
August 31, 2026
On-site
Boston, MA
Clinical Research and Development
Key Responsibilities:
- Develop vision, strategy, and capabilities for Biotherapeutics DMPK-Bioanalysis (DMPK-BA) teams across Boston and Seattle, aligned with Global DMPK-BA and Vertex R&D.
- Develop and execute DMPK-BA scientific strategies from discovery through clinical development, including preclinical PK, ADME, bioanalytical/immunogenicity assay design, execution, and interpretation, plus translational PKPD for dose selection and clinical projections.
- Communicate DMPK-BA findings, implications, and recommendations to teams, senior leadership, and governance bodies.
- Partner with Biology, Preclinical Safety, Clinical Pharmacology, CMC, and other R&D disciplines to align DMPK-BA strategy with program goals.
- Implement innovative technologies/approaches to improve scientific impact and efficiencies.
- Provide scientific and managerial leadership, prioritizing and delivering key projects.
- Ensure scientific excellence and regulatory compliance for DMPK documents/reports (e.g., investigator brochures, INDs/equivalents, marketing applications).
- Hire, develop, manage, and retain talent; build internal/external sourcing and contribute to resource allocation/capital planning.
- Participate in business development opportunity review.
Qualifications:
- PhD in Pharmacokinetics, Biochemistry, Biology, or related field; 15+ years industry experience at the management level.
- Track record managing DMPK-BA teams across multiple therapeutic areas; deep experience with biotherapeutic modalities (protein, antibody/nucleic acid therapeutics, cell/gene therapies).
- Strategic expertise in PK, ADME, bioanalysis, immunogenicity, biotransformation, and translational PKPD modeling for biologics.
- Excellent communication; ability to build cross-site/function collaborations.
- Experience preparing regulatory submissions and interacting with health authorities.
- Strong management/leadership, including mentoring.
Pay Range: $268,000 - $402,000
- Develop vision, strategy, and capabilities for Biotherapeutics DMPK-Bioanalysis (DMPK-BA) teams across Boston and Seattle, aligned with Global DMPK-BA and Vertex R&D.
- Develop and execute DMPK-BA scientific strategies from discovery through clinical development, including preclinical PK, ADME, bioanalytical/immunogenicity assay design, execution, and interpretation, plus translational PKPD for dose selection and clinical projections.
- Communicate DMPK-BA findings, implications, and recommendations to teams, senior leadership, and governance bodies.
- Partner with Biology, Preclinical Safety, Clinical Pharmacology, CMC, and other R&D disciplines to align DMPK-BA strategy with program goals.
- Implement innovative technologies/approaches to improve scientific impact and efficiencies.
- Provide scientific and managerial leadership, prioritizing and delivering key projects.
- Ensure scientific excellence and regulatory compliance for DMPK documents/reports (e.g., investigator brochures, INDs/equivalents, marketing applications).
- Hire, develop, manage, and retain talent; build internal/external sourcing and contribute to resource allocation/capital planning.
- Participate in business development opportunity review.
Qualifications:
- PhD in Pharmacokinetics, Biochemistry, Biology, or related field; 15+ years industry experience at the management level.
- Track record managing DMPK-BA teams across multiple therapeutic areas; deep experience with biotherapeutic modalities (protein, antibody/nucleic acid therapeutics, cell/gene therapies).
- Strategic expertise in PK, ADME, bioanalysis, immunogenicity, biotransformation, and translational PKPD modeling for biologics.
- Excellent communication; ability to build cross-site/function collaborations.
- Experience preparing regulatory submissions and interacting with health authorities.
- Strong management/leadership, including mentoring.
Pay Range: $268,000 - $402,000