Engineer III, mRNA Process Development-Downstream

Role: Engineer III responsible for downstream process development of mRNA drug substance, including design, optimization, scale-up, and technology transfer to GMP manufacturing sites. Objectives: develop scalable purification processes addressing mRNA-specific challenges, ensure smooth transfer to external CDMOs, and support GMP campaigns. Responsibilities: develop unit operations like chromatography, filtration, and impurity clearance; optimize process parameters; create transfer documentation; oversee technical transfers and troubleshoot during manufacturing; collaborate cross-functionally with upstream, analytical, formulation, and supply chain teams; and support process characterization for late-stage development. Requirements: BS in Chemical/Biochem Engineering or related field with 4-6+ years (MS with 2-5+ years), hands-on experience in biologics/nucleic acids downstream processing, process scale-up, and transfer to external sites; proficiency with chromatography, TFF, DoE, and engineering fundamentals; strong communication skills. Preferred: experience with mRNA, oligonucleotides, GMP campaigns, LNP formulation, and single-use tech. High-Value: focus on nucleic acid modalities, GMP process transfer, external manufacturing collaboration, and process optimization for scalable and compliant biotech production. Work setup: on-site in Boston, with no travel specified.