Engineer - Drug Substance Synthetic Molecule Design and Development
Eli Lilly and Company
18 days ago
On-site
Indianapolis, IN
Clinical Research and Development
Position Responsibilities
- Generate process design and unit operation knowledge based on engineering principles for small molecules and other emerging therapeutic modalities.
- Ensure successful scale-up of processes through fundamental engineering principles and equipment knowledge.
- Design and execute laboratory experiments (manual and automated high- and low-throughput reactors) to support crystallization process design and optimization.
- Develop drug substance processes and manufacturing technologies, defining API physical properties and designing crystallization processes to meet physical property and chemical purity requirements.
- Leverage/develop PAT, continuous processing, mechanistic models, and novel formulation platforms to build robust crystallization processes that enhance/tailor API physical properties.
- Apply engineering and business principles to design/characterize synthetic processes; use modeling tools to characterize kinetics, mechanisms, and separations.
- Create solutions to improve existing processes or develop novel ones.
- Transfer technical information to internal/external manufacturing sites; provide technical oversight to partners.
- Author/maintain documentation (lab notebooks, technical reports).
- Design process and equipment flow strategies; propose and implement new equipment/techniques/technologies.
- Utilize technology to improve safety, quality, and productivity; publish research externally.
Minimum Qualifications
- B.S. or M.S. in chemical engineering or closely related engineering field.
- Authorized to work in the United States full-time (Lilly does not sponsor visas/work authorization).
Additional Skills/Preferences
- Hands-on synthetic organic chemistry experience.
- Crystallization process design fundamentals (heat/mass transfer, thermodynamics, kinetics, separations, drying, milling, mixing theory, experimental design).
- Experience with PAT/analytical methods (image analysis, IR, Raman, FBRM; XRPD, DSC, TGA, particle sizing, microscopy).
- Strong problem-solving, communication, teamwork, and ability to prioritize amid ambiguity.
Additional Information
- Travel: 0–10%.
- Location: Indianapolis, IN (Lilly Technology Center – North).
- Generate process design and unit operation knowledge based on engineering principles for small molecules and other emerging therapeutic modalities.
- Ensure successful scale-up of processes through fundamental engineering principles and equipment knowledge.
- Design and execute laboratory experiments (manual and automated high- and low-throughput reactors) to support crystallization process design and optimization.
- Develop drug substance processes and manufacturing technologies, defining API physical properties and designing crystallization processes to meet physical property and chemical purity requirements.
- Leverage/develop PAT, continuous processing, mechanistic models, and novel formulation platforms to build robust crystallization processes that enhance/tailor API physical properties.
- Apply engineering and business principles to design/characterize synthetic processes; use modeling tools to characterize kinetics, mechanisms, and separations.
- Create solutions to improve existing processes or develop novel ones.
- Transfer technical information to internal/external manufacturing sites; provide technical oversight to partners.
- Author/maintain documentation (lab notebooks, technical reports).
- Design process and equipment flow strategies; propose and implement new equipment/techniques/technologies.
- Utilize technology to improve safety, quality, and productivity; publish research externally.
Minimum Qualifications
- B.S. or M.S. in chemical engineering or closely related engineering field.
- Authorized to work in the United States full-time (Lilly does not sponsor visas/work authorization).
Additional Skills/Preferences
- Hands-on synthetic organic chemistry experience.
- Crystallization process design fundamentals (heat/mass transfer, thermodynamics, kinetics, separations, drying, milling, mixing theory, experimental design).
- Experience with PAT/analytical methods (image analysis, IR, Raman, FBRM; XRPD, DSC, TGA, particle sizing, microscopy).
- Strong problem-solving, communication, teamwork, and ability to prioritize amid ambiguity.
Additional Information
- Travel: 0–10%.
- Location: Indianapolis, IN (Lilly Technology Center – North).