Downstream Process Development Co-Op

Company: Keros Therapeutics

At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients.

Job Summary

This role is responsible for experiment execution in downstream biologics process development. This will include equipment setup, maintenance, processing, and data acquisition in a laboratory setting. Technical report authoring and lab notebook recordkeeping are also critical to this role. A successful candidate will exhibit strong interpersonal skills, technical competence, and a willingness to learn.

Primary Responsibilities

• Scale-down and range finding study execution
• Purification by FPLC of Pilot scale batches
• Implementation of multiple liquid chromatography types (i.e Affinity, Ion Exchange, HIC)
• Buffer formulation, resin selection and capacity study execution
• Filter loading and fouling study execution
• Intermediate stability analysis
• Formulation and stability study support
• Protein characterization by A280, SEC, SDS-PAGE and cIEF
• Statistical data analysis
• Equipment setup, functional verification and maintenance

Qualifications

• Currently enrolled in a biology, chemistry, chemical engineering, bioengineering, molecular biology or related program
• Familiar with protein biochemistry
• Familiar with general biology lab techniques
• Familiar with statistical analysis and experimental design
• Technical and scientific writing and presentation skills

Our Diversity, Equity & Inclusion Mission Statement

Keros is an inclusive company. We believe that diversity drives innovation. We continue to build an inclusive culture that encourages, supports, and celebrates the diverse voices of our employees. As such, Keros takes a holistic approach in mentoring, coaching, and developing all of our Keros team members.

Equal Opportunity Employer

Keros Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Recruitment & Staffing Agencies

Keros Therapeutics does not accept unsolicited resumes from any source other than the candidate directly. Any unsolicited submission by an agency to Keros is prohibited. Any resume submitted by an agency without a signed contract or expressed consent by a member of the Keros Therapeutics Human Resources Department, will be considered property of Keros Therapeutics, and no fee shall be owed with respect thereto.