Downstream Engineer III
Takeda
August 15, 2026
On-site
Lexington, MA
$89,900 - $141,240 USD yearly
Operations
Downstream Process Development, Engineer III
Responsibilities:
- Execute chromatography, harvest operations, ultrafiltration/diafiltration, and viral clearance experiments (may also support bioconjugation).
- Support downstream biotherapeutics process development across micro, bench, and pilot scales for early- and late-stage programs.
- Maintain laboratory equipment and support instrument readiness.
- Plan and execute larger experiments with more senior process engineers.
- Document experiments in electronic laboratory notebooks; maintain timely, complete records.
- Perform basic data analysis and support study conclusions.
- Prepare technical summaries and written study updates.
- Follow established lab/process development procedures, including quality and safety requirements.
- Identify continuous improvement opportunities in workflows, data capture, and experimental execution.
- Assist with small projects/tasks under close supervision; advise peers/junior team members when needed.
Qualifications/Requirements:
- Bachelor’s degree with 2+ years relevant experience, or Master’s degree with relevant experience, in chemical engineering, chemistry, biochemistry, biotechnology, or related field.
- Experience with chromatography, harvest, ultrafiltration/diafiltration, and viral clearance steps.
- Some relevant experience in process development, protein purification, or related lab setting.
- Experience with basic bioprocess control systems.
- Experience using electronic laboratory notebooks.
- Ability to perform basic data analysis and present results clearly in writing.
- Familiarity with technical writing.
- Understanding of lab practices, process development methods, and quality requirements.
- Ability to follow detailed procedures and maintain accurate records under close supervision.
- Comfort with emerging digital tools and AI-enabled processes for data analysis/documentation/workflow improvement.
Application instructions: By clicking the “Apply” button, your employment application process with Takeda will commence.
Responsibilities:
- Execute chromatography, harvest operations, ultrafiltration/diafiltration, and viral clearance experiments (may also support bioconjugation).
- Support downstream biotherapeutics process development across micro, bench, and pilot scales for early- and late-stage programs.
- Maintain laboratory equipment and support instrument readiness.
- Plan and execute larger experiments with more senior process engineers.
- Document experiments in electronic laboratory notebooks; maintain timely, complete records.
- Perform basic data analysis and support study conclusions.
- Prepare technical summaries and written study updates.
- Follow established lab/process development procedures, including quality and safety requirements.
- Identify continuous improvement opportunities in workflows, data capture, and experimental execution.
- Assist with small projects/tasks under close supervision; advise peers/junior team members when needed.
Qualifications/Requirements:
- Bachelor’s degree with 2+ years relevant experience, or Master’s degree with relevant experience, in chemical engineering, chemistry, biochemistry, biotechnology, or related field.
- Experience with chromatography, harvest, ultrafiltration/diafiltration, and viral clearance steps.
- Some relevant experience in process development, protein purification, or related lab setting.
- Experience with basic bioprocess control systems.
- Experience using electronic laboratory notebooks.
- Ability to perform basic data analysis and present results clearly in writing.
- Familiarity with technical writing.
- Understanding of lab practices, process development methods, and quality requirements.
- Ability to follow detailed procedures and maintain accurate records under close supervision.
- Comfort with emerging digital tools and AI-enabled processes for data analysis/documentation/workflow improvement.
Application instructions: By clicking the “Apply” button, your employment application process with Takeda will commence.