Discovery Synthesis & Purification Co-op (Fall 2026)

Role Summary

Discovery Synthesis & Purification Co-op (Fall 2026) at Wave Life Sciences. The co-op will join a team of scientists in Lexington, MA, gaining exposure to oligonucleotide synthesis, formulation, purification, and analysis. The position includes training in a variety of laboratory techniques and instrumentation, and is ideal for a student with strong organizational skills and attention to detail who thrives in a team-oriented, fast-paced, multidisciplinary biotech environment. Completion of coursework in organic chemistry, biochemistry, or analytical chemistry with laboratory experience is preferred.

Responsibilities

• Perform downstream processing of oligonucleotides synthesized at various scales, utilizing various purification modalities, but specifically Anion Exchange (AEX) chromatography and size exclusion chromatography (SEC).
• Learn the AKTA Unicorn software to assist in developing new methods/gradients
• Characterize compounds using analytical instrumentation i.e., UV, pH, UPLC and LC-MS
• Operate and maintain lab equipment such as synthesizers, ÄKTA purifiers, UPLC, LC-MS, Nanodrop, and other analytical instrumentation
• Maintain timely, detailed written and electronic records of experimental protocols and data in accordance with company policy
• Potential to learn synthesis of oligonucleotides on the MM12, MM192 and AKTA synthesis systems if timing allows

Qualifications

• Required: Strong organizational skills and attention to detail
• Required: Thrives in a team-oriented, fast-paced and multi-disciplinary biotech environment
• Required: Effective and timely communication skills both interdepartmentally and with vested stakeholders, including presenting scientific data
• Required: Strict adherence to lab safety and personal protective equipment policies
• Preferred: Completion of coursework in organic chemistry, biochemistry, analytical chemistry with laboratory experience

Skills

• An inquisitive student with a positive attitude with a desire to succeed and promote change to improve efficiencies