Discovery Immunology Principal Research Scientist
Vertex Pharmaceuticals
September 01, 2026
Full-time
On-site
Seattle, WA
Clinical Research and Development
Role: Lead immunology discovery programs focusing on autoimmune diseases, responsible for target identification, validation, and elucidating disease mechanisms. Core duties include designing and interpreting in vitro, ex vivo, and in vivo studies across immune pathways, developing disease models, and guiding translational strategies. Collaborates with multidisciplinary teams in biology, bioinformatics, and project management; mentors scientists and contributes to scientific dissemination. Requirements: PhD in immunology or related field, or 10+ years of relevant laboratory experience; extensive expertise in immune pathway analysis, immune cell profiling, cytokine signaling, and disease modeling; strong publication record; proven industry or postdoctoral research leadership. Preferred skills include experience with immune-stromal co-cultures, systems immunology, and bioinformatics approaches. High-value specifics: autoimmune/inflammatory disease focus, early discovery stage, laboratory-based on-site role, with an emphasis on experimental immunology, translational science, and collaborative research environment.