Discovery ADME Project Leader (Radioligand Therapeutics)

Role: Discovery ADME Project Leader specializing in Radioligand Therapeutics (Radioconjugates), responsible for developing and executing integrated preclinical ADME strategies to inform candidate selection and optimize drug properties. Responsibilities: provide mechanistic understanding of drug disposition, PK, metabolism, and translational science; guide compound design, interpret exposure-toxicity relationships, and support dose and PK/PD modeling; collaborate across functions such as Medicinal Chemistry, DMPK, Toxicology, and Pharmacology; lead ADME strategy in project teams, ensure regulatory compliance, and mentor junior scientists. Requirements: PhD in Pharmaceutical Sciences, Pharmacokinetics, Drug Metabolism, or related field; minimum 2 years post-graduation industry experience in Radioligand Therapeutics discovery; deep ADME expertise with knowledge of medicinal chemistry and toxicology principles advantageous. High-Value: radioconjugates, ADME-driven drug discovery, early-stage preclinical research, cross-functional collaboration, global locations (Boston, Louisville, Indianapolis), and emphasis on mechanistic modeling, safety, and regulatory readiness.