Discovery ADME Project Leader
Eli Lilly and Company
August 07, 2026
Remote friendly (Indianapolis, IN)
United States
Clinical Research and Development
Job Title: Discovery ADME Project Leader
Position Summary:
Provide deep mechanistic understanding of drug disposition, PK, and translational science; integrate biology, chemistry, and modeling to develop ambitious Target Product Profiles and molecule design strategy, ensuring teams advance “The Right Molecule to The Right Study at The Right Time.”
Geography:
Open to Boston, MA; Louisville, CO; or Indianapolis, IN.
Responsibilities:
- Keep Safety as a priority.
- Develop and execute integrated preclinical ADME strategies aligned with discovery stage, TPP, design hypotheses, and regulatory expectations.
- Integrate ADME and pharmacology to enable translational simulations and modeling (dose selection; PK/PD, efficacy, and safety).
- Define profiling and decision funnels across in silico, in vitro, in vivo to translational modeling.
- Guide compound design/optimization using data-driven principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Own ADME strategy as single-point-of-accountability on cross-functional teams; translate ADME findings into design/test hypotheses.
- Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology; contribute to go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
- Represent ADME in portfolio governance and leadership reviews.
- Implement best practices/assay innovation/automation; drive continuous improvement in reporting and knowledge; deploy AI/agentic tools where possible.
- Maintain inspection-ready documentation aligned to regulatory expectations.
- Mentor and grow junior scientists.
Qualifications:
- PhD (or equivalent) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field.
- 3+ years post-graduation industry experience in drug discovery; understand the ADME Project Leader impact across Design, Make, Test, Analyze.
Preferred/Additional:
- Deep ADME expertise; working knowledge of medicinal chemistry and Toxicology principles.
- Ability to translate technical concepts into strategic value for senior leadership and cross-functional partners.
Position Summary:
Provide deep mechanistic understanding of drug disposition, PK, and translational science; integrate biology, chemistry, and modeling to develop ambitious Target Product Profiles and molecule design strategy, ensuring teams advance “The Right Molecule to The Right Study at The Right Time.”
Geography:
Open to Boston, MA; Louisville, CO; or Indianapolis, IN.
Responsibilities:
- Keep Safety as a priority.
- Develop and execute integrated preclinical ADME strategies aligned with discovery stage, TPP, design hypotheses, and regulatory expectations.
- Integrate ADME and pharmacology to enable translational simulations and modeling (dose selection; PK/PD, efficacy, and safety).
- Define profiling and decision funnels across in silico, in vitro, in vivo to translational modeling.
- Guide compound design/optimization using data-driven principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Own ADME strategy as single-point-of-accountability on cross-functional teams; translate ADME findings into design/test hypotheses.
- Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology; contribute to go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
- Represent ADME in portfolio governance and leadership reviews.
- Implement best practices/assay innovation/automation; drive continuous improvement in reporting and knowledge; deploy AI/agentic tools where possible.
- Maintain inspection-ready documentation aligned to regulatory expectations.
- Mentor and grow junior scientists.
Qualifications:
- PhD (or equivalent) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field.
- 3+ years post-graduation industry experience in drug discovery; understand the ADME Project Leader impact across Design, Make, Test, Analyze.
Preferred/Additional:
- Deep ADME expertise; working knowledge of medicinal chemistry and Toxicology principles.
- Ability to translate technical concepts into strategic value for senior leadership and cross-functional partners.