Discovery ADME Project Leader
Eli Lilly and Company
August 29, 2026
Remote friendly (Louisville, CO)
United States
Clinical Research and Development
Job Title: Discovery ADME Project Leader
What You Will Do
- Keep Safety as a priority.
- Develop and execute integrated preclinical ADME strategies aligned with discovery stage, TPP, design hypotheses, and regulatory expectations.
- Integrate ADME and pharmacology to enable translational simulations and modeling (dose selection, PK/PD design, efficacy, safety).
- Define stage-, modality-, and issue-appropriate profiling and decision funnels (in silico, in vitro, in vivo to translational modeling).
- Guide compound design/optimization via data-driven principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Serve as ADME strategy and single-point-of-accountability on cross-functional program teams; translate ADME findings into design/test hypotheses.
- Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions; support go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
- Represent ADME in portfolio governance and leadership reviews.
- Implement best practices, assay innovation/automation; drive continuous improvement in data reporting/knowledge management; seek/deploy AI/agentic tools where possible.
- Maintain inspection-ready documentation and regulatory alignment.
- Mentor, teach, and grow junior scientists.
Qualifications
- PhD (or equivalent) in Pharmaceutical Sciences, Pharmacokinetics/Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field.
- 3+ years of post-graduation industry experience in drug discovery; experience leading discovery teams and understanding ADME Project Leader impact on Design-Make-Test-Analyze.
Additional Qualifications (Preferred)
- Deep ADME expertise with working knowledge of medicinal chemistry and toxicology.
- Ability to translate complex technical concepts into strategic value for senior leadership and cross-functional partners.
Application Instructions
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation
What You Will Do
- Keep Safety as a priority.
- Develop and execute integrated preclinical ADME strategies aligned with discovery stage, TPP, design hypotheses, and regulatory expectations.
- Integrate ADME and pharmacology to enable translational simulations and modeling (dose selection, PK/PD design, efficacy, safety).
- Define stage-, modality-, and issue-appropriate profiling and decision funnels (in silico, in vitro, in vivo to translational modeling).
- Guide compound design/optimization via data-driven principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Serve as ADME strategy and single-point-of-accountability on cross-functional program teams; translate ADME findings into design/test hypotheses.
- Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions; support go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
- Represent ADME in portfolio governance and leadership reviews.
- Implement best practices, assay innovation/automation; drive continuous improvement in data reporting/knowledge management; seek/deploy AI/agentic tools where possible.
- Maintain inspection-ready documentation and regulatory alignment.
- Mentor, teach, and grow junior scientists.
Qualifications
- PhD (or equivalent) in Pharmaceutical Sciences, Pharmacokinetics/Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field.
- 3+ years of post-graduation industry experience in drug discovery; experience leading discovery teams and understanding ADME Project Leader impact on Design-Make-Test-Analyze.
Additional Qualifications (Preferred)
- Deep ADME expertise with working knowledge of medicinal chemistry and toxicology.
- Ability to translate complex technical concepts into strategic value for senior leadership and cross-functional partners.
Application Instructions
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation