Discovery ADME Project Leader
Eli Lilly and Company
August 07, 2026
Remote friendly (Louisville, CO)
United States
Clinical Research and Development
Job Title: Discovery ADME Project Leader
What You Will Do
- Keep Safety as a priority.
- Develop and execute integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses, and regulatory expectations.
- Integrate ADME and pharmacology to enable translational simulations/modeling for dose selection, PK/PD design, efficacy, and safety studies.
- Define stage-, modality-, and issue-appropriate profiling and decision funnels (in silico, in vitro, in vivo to translational modeling).
- Guide compound design/optimization using data-driven principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Serve as ADME strategy and single-point-of-accountability on cross-functional program teams; translate ADME findings into design/test hypotheses.
- Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions; support go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
- Represent ADME in portfolio governance and leadership reviews.
- Implement best practices, assay innovation, and automation; drive continuous improvement in data reporting/knowledge/decision frameworks; leverage AI/agentic tools where possible.
- Maintain inspection-ready documentation aligned with regulatory expectations.
- Mentor, teach, and grow junior scientists.
Qualifications
- PhD (or equivalent) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field.
- 3+ years post-graduation industry experience in drug discovery; leadership impact on discovery lifecycle (Design, Make, Test, Analyze).
Additional Qualifications (Preferred)
- Deep ADME expertise; working knowledge of medicinal chemistry and Toxicology principles.
- Experience translating technical concepts into strategic value for senior leadership and cross-functional partners.
Geography: Boston MA, Louisville CO, or Indianapolis IN.
Benefits (if eligible)
- 401(k), pension, vacation, medical/dental/vision/prescription benefits, flexible benefits, life insurance/death benefits, time off/leave, well-being benefits (EAP, fitness, employee clubs/activities).
What You Will Do
- Keep Safety as a priority.
- Develop and execute integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses, and regulatory expectations.
- Integrate ADME and pharmacology to enable translational simulations/modeling for dose selection, PK/PD design, efficacy, and safety studies.
- Define stage-, modality-, and issue-appropriate profiling and decision funnels (in silico, in vitro, in vivo to translational modeling).
- Guide compound design/optimization using data-driven principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Serve as ADME strategy and single-point-of-accountability on cross-functional program teams; translate ADME findings into design/test hypotheses.
- Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions; support go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
- Represent ADME in portfolio governance and leadership reviews.
- Implement best practices, assay innovation, and automation; drive continuous improvement in data reporting/knowledge/decision frameworks; leverage AI/agentic tools where possible.
- Maintain inspection-ready documentation aligned with regulatory expectations.
- Mentor, teach, and grow junior scientists.
Qualifications
- PhD (or equivalent) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field.
- 3+ years post-graduation industry experience in drug discovery; leadership impact on discovery lifecycle (Design, Make, Test, Analyze).
Additional Qualifications (Preferred)
- Deep ADME expertise; working knowledge of medicinal chemistry and Toxicology principles.
- Experience translating technical concepts into strategic value for senior leadership and cross-functional partners.
Geography: Boston MA, Louisville CO, or Indianapolis IN.
Benefits (if eligible)
- 401(k), pension, vacation, medical/dental/vision/prescription benefits, flexible benefits, life insurance/death benefits, time off/leave, well-being benefits (EAP, fitness, employee clubs/activities).