Discovery ADME Project Leader

Role: Discovery ADME Project Leader responsible for developing and executing integrated preclinical ADME strategies to support early-stage drug discovery. Core responsibilities include guiding compound design and optimization through data-driven principles, enabling translational PK/PD modeling, and collaborating with cross-functional teams (Medicinal Chemistry, DMPK, Toxicology, Pharmacology) to ensure high-quality candidate selection. The role involves representing ADME in portfolio reviews, implementing assay innovation, driving continuous improvement, and mentoring junior scientists. Qualifications: PhD in Pharmaceutical Sciences, Pharmacokinetics, or related field; 3+ years in drug discovery; deep ADME expertise with knowledge of medicinal chemistry and toxicology principles advantageous. High-value biopharma specifics: focus on small molecules, with experience in pan-modality chemotypes, early discovery stage, emphasizing translational science, PK/PD modeling, and regulatory readiness. Location is flexible to Boston MA, Louisville CO, or Indianapolis IN.