Director Translational Science Lead Respiratory
GSK
8 hours ago
Remote friendly (Durham, NC)
United States
Clinical Research and Development
Key Responsibilities:
- Disease Biomarker Strategy Development and Delivery: Partner with Clinical Teams, R&D Technologies, and the RIIRU Early Pipeline Unit (Respiratory portfolio) to identify, establish, and validate disease-relevant biomarkers, mechanistic/surrogate biomarkers, and support patient stratification and differentiated response prediction; deploy biomarkers into clinical studies and interpret results.
- Translational Leadership: Provide strategic leadership to develop and execute translational research disease strategies supporting discovery and development of novel differentiated therapeutics, including evaluation and diligence of business development opportunities.
- Translational Innovation: Evaluate novel techniques/technologies (e.g., spatial transcriptomics) for translational initiatives, biomarker development, and validation; identify and guide validation of human assays (cells, tissues, organs) to enhance human translation and predictive value using resources such as the Human Cell Atlas, disease tissue multi-omics data, and genetic resources.
- Cross-functional Collaboration: Collaborate with translational disease teams, biology groups, biomarker platforms, medicine development teams, HBSM, data sciences, regulatory affairs, business development, and commercial across the drug development lifecycle.
- External Partnerships: Establish/maintain collaborations with academic institutions and CROs to access technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities; build a network of external experts/KOLs; support evaluation and diligence of business development opportunities.
- Matrix Leadership: Mentor and develop a high-performing team; manage disease/project resources, budgets, and timelines; represent Translational Science in portfolio governance reviews.
Basic Qualifications (Required):
- Ph.D. in a Scientific/Life Science discipline.
- Extensive experience in translational science and biomarker development (pharma/biotech preferred).
- Recognized translational/biomarker expert (publications/contributions).
- Experience implementing translational science and biomarkers in Respiratory indications.
- Experience in clinical trial settings; authoring and oversight of clinical and regulatory documents.
- Knowledge of regulatory requirements, industry standards, best practices, and compliance for translational research/biomarker validation.
- Experience with translational research technologies/methods.
- Proven track record using biomarker strategies to support program decisions through clinical transition milestones.
- Experience leading/managing external collaborations and business development evaluations.
- Experienced matrix leader who can foster psychological safety and motivate teams.
Preferred Qualifications:
- Awareness of bioinformatic/computational methods for integrated translational/biomarker data analysis.
- Strong management skills to prioritize multiple objectives and meet timelines.
- Experience in fast-paced evolving research environments with strong problem-solving and critical thinking.
Work Location:
- UK or US; hybrid working model.
Compensation/Benefits (explicitly stated):
- US base salary (for certain locations): $189,750 to $316,250; annual bonus; eligibility for share-based long-term incentive; health insurance (employee and family), retirement benefits, paid holidays, vacation, paid caregiver/parental and medical leave.
Application Instructions:
- Not provided in the text.
- Disease Biomarker Strategy Development and Delivery: Partner with Clinical Teams, R&D Technologies, and the RIIRU Early Pipeline Unit (Respiratory portfolio) to identify, establish, and validate disease-relevant biomarkers, mechanistic/surrogate biomarkers, and support patient stratification and differentiated response prediction; deploy biomarkers into clinical studies and interpret results.
- Translational Leadership: Provide strategic leadership to develop and execute translational research disease strategies supporting discovery and development of novel differentiated therapeutics, including evaluation and diligence of business development opportunities.
- Translational Innovation: Evaluate novel techniques/technologies (e.g., spatial transcriptomics) for translational initiatives, biomarker development, and validation; identify and guide validation of human assays (cells, tissues, organs) to enhance human translation and predictive value using resources such as the Human Cell Atlas, disease tissue multi-omics data, and genetic resources.
- Cross-functional Collaboration: Collaborate with translational disease teams, biology groups, biomarker platforms, medicine development teams, HBSM, data sciences, regulatory affairs, business development, and commercial across the drug development lifecycle.
- External Partnerships: Establish/maintain collaborations with academic institutions and CROs to access technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities; build a network of external experts/KOLs; support evaluation and diligence of business development opportunities.
- Matrix Leadership: Mentor and develop a high-performing team; manage disease/project resources, budgets, and timelines; represent Translational Science in portfolio governance reviews.
Basic Qualifications (Required):
- Ph.D. in a Scientific/Life Science discipline.
- Extensive experience in translational science and biomarker development (pharma/biotech preferred).
- Recognized translational/biomarker expert (publications/contributions).
- Experience implementing translational science and biomarkers in Respiratory indications.
- Experience in clinical trial settings; authoring and oversight of clinical and regulatory documents.
- Knowledge of regulatory requirements, industry standards, best practices, and compliance for translational research/biomarker validation.
- Experience with translational research technologies/methods.
- Proven track record using biomarker strategies to support program decisions through clinical transition milestones.
- Experience leading/managing external collaborations and business development evaluations.
- Experienced matrix leader who can foster psychological safety and motivate teams.
Preferred Qualifications:
- Awareness of bioinformatic/computational methods for integrated translational/biomarker data analysis.
- Strong management skills to prioritize multiple objectives and meet timelines.
- Experience in fast-paced evolving research environments with strong problem-solving and critical thinking.
Work Location:
- UK or US; hybrid working model.
Compensation/Benefits (explicitly stated):
- US base salary (for certain locations): $189,750 to $316,250; annual bonus; eligibility for share-based long-term incentive; health insurance (employee and family), retirement benefits, paid holidays, vacation, paid caregiver/parental and medical leave.
Application Instructions:
- Not provided in the text.