Director, Translational Pharmacology
Travere Therapeutics
August 08, 2026
Remote friendly (United States)
United States
Clinical Research and Development
Position Summary:
Director, Translational Pharmacology—serve as a key scientific contributor to external evaluation of business development opportunities (rare disease), assessing therapeutic rationale, disease biology, mechanism of action, translational strategy, pharmacology data, biomarker approaches, and development feasibility. Integrate nonclinical, clinical, competitive, and translational data to support decision-making and contribute to internal/external translational pharmacology activities.
Responsibilities:
- Act as preclinical biology lead/key contributor for BD opportunities (small molecules to biologics) across stages.
- Assess rationale, MoA, disease biology, pharmacology/toxicology, translational relevance, safety window, biomarker strategy, and feasibility.
- Review nonclinical/translational data with clinical/regulatory/competitive input; identify strengths/risks/gaps/value drivers.
- Partner with BD diligence teams on scientific assessment reports, diligence questions, risk summaries, and recommendations.
- Identify critical experiments/analyses/expert input to reduce uncertainty.
- Provide translational pharmacology expertise (in vitro/in vivo/ex vivo/PD/clinical pharmacology; biomarkers).
- Evaluate support for MoA, target engagement, dose rationale, patient selection, and clinical strategy.
- Lead/contribute to external scientific engagement (companies, academia, CROs, KOLs); represent Travere at external forums.
- Support nonclinical/regulatory needs (package adequacy, development plans/budgets, investigator/briefing/regulatory sections, identify gaps).
- Provide scientific leadership, mentor colleagues, manage concurrent diligence/program activities.
Qualifications (Required):
- Bachelor’s in Life Science/related field; PhD/MD/PharmD preferred.
- Minimum 10 years biopharma experience (or 6 years with advanced degree).
- Strong nonclinical/clinical pharmacology knowledge.
- Experience evaluating drug candidates, MoA, disease biology, and translational data to support decisions.
- Working knowledge of regulatory expectations for nonclinical/translational support.
- Leadership of scientific initiatives/workstreams/teams.
- Ability to synthesize complex data, communicate recommendations, and manage priorities.
Preferred:
- Rare disease/rare metabolic/nephrology/immunology/inflammation experience.
- Due diligence experience (licensing/acquisition/collaboration).
- IND nonclinical toxicology/safety experience.
- Translational plan experience (MoA → target engagement/PD → biomarkers → outcomes).
- Biomarker strategy/patient selection/human translational systems expertise.
- CRO/academic/external expert collaboration.
- Executive-level diligence/report/governance presentation experience.
Benefits:
- Premium health, financial, work-life/well-being offerings; wellness/support programs; life insurance; disability; retirement with match; generous paid time off.
Compensation:
- Target base pay range: $189,000–$246,000.
Application Instructions:
- Travere accepts applications on an ongoing basis until a candidate is selected.
Director, Translational Pharmacology—serve as a key scientific contributor to external evaluation of business development opportunities (rare disease), assessing therapeutic rationale, disease biology, mechanism of action, translational strategy, pharmacology data, biomarker approaches, and development feasibility. Integrate nonclinical, clinical, competitive, and translational data to support decision-making and contribute to internal/external translational pharmacology activities.
Responsibilities:
- Act as preclinical biology lead/key contributor for BD opportunities (small molecules to biologics) across stages.
- Assess rationale, MoA, disease biology, pharmacology/toxicology, translational relevance, safety window, biomarker strategy, and feasibility.
- Review nonclinical/translational data with clinical/regulatory/competitive input; identify strengths/risks/gaps/value drivers.
- Partner with BD diligence teams on scientific assessment reports, diligence questions, risk summaries, and recommendations.
- Identify critical experiments/analyses/expert input to reduce uncertainty.
- Provide translational pharmacology expertise (in vitro/in vivo/ex vivo/PD/clinical pharmacology; biomarkers).
- Evaluate support for MoA, target engagement, dose rationale, patient selection, and clinical strategy.
- Lead/contribute to external scientific engagement (companies, academia, CROs, KOLs); represent Travere at external forums.
- Support nonclinical/regulatory needs (package adequacy, development plans/budgets, investigator/briefing/regulatory sections, identify gaps).
- Provide scientific leadership, mentor colleagues, manage concurrent diligence/program activities.
Qualifications (Required):
- Bachelor’s in Life Science/related field; PhD/MD/PharmD preferred.
- Minimum 10 years biopharma experience (or 6 years with advanced degree).
- Strong nonclinical/clinical pharmacology knowledge.
- Experience evaluating drug candidates, MoA, disease biology, and translational data to support decisions.
- Working knowledge of regulatory expectations for nonclinical/translational support.
- Leadership of scientific initiatives/workstreams/teams.
- Ability to synthesize complex data, communicate recommendations, and manage priorities.
Preferred:
- Rare disease/rare metabolic/nephrology/immunology/inflammation experience.
- Due diligence experience (licensing/acquisition/collaboration).
- IND nonclinical toxicology/safety experience.
- Translational plan experience (MoA → target engagement/PD → biomarkers → outcomes).
- Biomarker strategy/patient selection/human translational systems expertise.
- CRO/academic/external expert collaboration.
- Executive-level diligence/report/governance presentation experience.
Benefits:
- Premium health, financial, work-life/well-being offerings; wellness/support programs; life insurance; disability; retirement with match; generous paid time off.
Compensation:
- Target base pay range: $189,000–$246,000.
Application Instructions:
- Travere accepts applications on an ongoing basis until a candidate is selected.