Director, Translational Pharmacology
Travere Therapeutics
August 29, 2026
Remote friendly (United States)
United States
Clinical Research and Development
Position Summary:
Director, Translational Pharmacology—key scientific contributor to external evaluation of business development opportunities in the rare disease space; assess therapeutic rationale, disease biology, mechanism of action, translational strategy, pharmacology data, biomarker approaches, and development feasibility. Integrates nonclinical, clinical, competitive, and translational data to support decisions; contributes to internal translational pharmacology activities and external collaborations.
Responsibilities:
- Serve as preclinical biology lead/key contributor for diligence of small-molecule to biologics opportunities.
- Assess rationale, mechanism of action, pharmacology/toxicology, translational relevance, therapeutic safety window, biomarker strategy, and feasibility.
- Review/interpet nonclinical/translational data with clinical, regulatory, and competitive information; identify strengths, risks, gaps, value drivers.
- Partner on diligence reports, questions, risk summaries, and recommendations; identify critical experiments/expert input to reduce uncertainty.
- Provide translational pharmacology across preclinical and clinical-stage opportunities (in vitro/in vivo/ex vivo, biomarkers, PD, clinical pharmacology).
- Evaluate dose rationale, patient selection, and clinical development strategy; integrate mechanistic biology and biomarker/clinical observations.
- Engage external experts/companies/academia/CROs; represent Travere in scientific forums.
- Support nonclinical/regulatory expectations; evaluate nonclinical package adequacy; contribute to development plans/budgets and related regulatory document sections.
- Provide scientific leadership, mentor colleagues, manage multiple concurrent activities.
Qualifications:
- Bachelor’s degree in Life Science or related required; PhD/MD/PharmD or equivalent preferred.
- Minimum 10 years biopharmaceutical industry experience required (or 6 years with advanced degree).
- Strong nonclinical/clinical pharmacology knowledge; experience evaluating drug candidates/biology/MoA/pharmacology data.
- Working knowledge of regulatory expectations for nonclinical/translational support.
- Experience leading scientific initiatives and synthesizing complex data into recommendations; excellent communication.
Preferred:
- Rare disease experience (e.g., nephrology, immunology, inflammation, rare metabolic).
- IND safety/toxicology experience; experience in formal due diligence.
- Translational plan development; biomarker and patient selection familiarity; CRO/academic expert collaboration.
Benefits:
- Premium health, financial/work-life/well-being offerings, wellness support, life insurance, disability, retirement match, generous paid time off.
- Target base pay range: $189,000–$246,000.
Application instructions:
- Apply on an ongoing basis until a candidate is selected.
Director, Translational Pharmacology—key scientific contributor to external evaluation of business development opportunities in the rare disease space; assess therapeutic rationale, disease biology, mechanism of action, translational strategy, pharmacology data, biomarker approaches, and development feasibility. Integrates nonclinical, clinical, competitive, and translational data to support decisions; contributes to internal translational pharmacology activities and external collaborations.
Responsibilities:
- Serve as preclinical biology lead/key contributor for diligence of small-molecule to biologics opportunities.
- Assess rationale, mechanism of action, pharmacology/toxicology, translational relevance, therapeutic safety window, biomarker strategy, and feasibility.
- Review/interpet nonclinical/translational data with clinical, regulatory, and competitive information; identify strengths, risks, gaps, value drivers.
- Partner on diligence reports, questions, risk summaries, and recommendations; identify critical experiments/expert input to reduce uncertainty.
- Provide translational pharmacology across preclinical and clinical-stage opportunities (in vitro/in vivo/ex vivo, biomarkers, PD, clinical pharmacology).
- Evaluate dose rationale, patient selection, and clinical development strategy; integrate mechanistic biology and biomarker/clinical observations.
- Engage external experts/companies/academia/CROs; represent Travere in scientific forums.
- Support nonclinical/regulatory expectations; evaluate nonclinical package adequacy; contribute to development plans/budgets and related regulatory document sections.
- Provide scientific leadership, mentor colleagues, manage multiple concurrent activities.
Qualifications:
- Bachelor’s degree in Life Science or related required; PhD/MD/PharmD or equivalent preferred.
- Minimum 10 years biopharmaceutical industry experience required (or 6 years with advanced degree).
- Strong nonclinical/clinical pharmacology knowledge; experience evaluating drug candidates/biology/MoA/pharmacology data.
- Working knowledge of regulatory expectations for nonclinical/translational support.
- Experience leading scientific initiatives and synthesizing complex data into recommendations; excellent communication.
Preferred:
- Rare disease experience (e.g., nephrology, immunology, inflammation, rare metabolic).
- IND safety/toxicology experience; experience in formal due diligence.
- Translational plan development; biomarker and patient selection familiarity; CRO/academic expert collaboration.
Benefits:
- Premium health, financial/work-life/well-being offerings, wellness support, life insurance, disability, retirement match, generous paid time off.
- Target base pay range: $189,000–$246,000.
Application instructions:
- Apply on an ongoing basis until a candidate is selected.