Director, Translational Pharmacology
Travere Therapeutics
August 30, 2026
Remote friendly (San Diego Metropolitan Area)
United States
Clinical Research and Development
Position Summary:
Director, Translational Pharmacology (Research & Nonclinical Development). Serve as a key scientific contributor to external business development evaluation, assessing therapeutic rationale, disease biology, mechanism of action, translational strategy, pharmacology data, biomarker approaches, and development feasibility; support internal translational pharmacology activities as needed.
Responsibilities:
- Act as preclinical biology lead/key contributor for diligence of small-molecule through biologics opportunities (assets, platform tech, collaborations).
- Assess MoA, disease biology, pharmacology/toxicology, translational relevance, safety window, biomarker strategy, and development feasibility.
- Integrate nonclinical/translational with clinical, regulatory, and competitive data to identify strengths/risks/gaps/value drivers.
- Partner with BD and diligence teams to develop scientific assessment reports, diligence questions, risk summaries, and recommendations.
- Identify critical experiments/expert input to reduce scientific uncertainty.
- Provide translational pharmacology expertise across in vitro/in vivo/ex vivo, biomarkers, PD, and clinical pharmacology data.
- Evaluate target engagement, dose rationale, patient selection, and clinical development strategy.
- Engage external experts/companies/academia/CROs; represent company in scientific forums.
- Interpret data in regulatory/clinical context; evaluate adequacy of nonclinical packages.
- Support development plans/budgets; contribute to investigator brochures, briefing documents, regulatory submissions, and development documents.
- Identify nonclinical/translational gaps impacting timelines/regulatory strategy/probability of success.
- Provide scientific leadership, mentor colleagues, and manage multiple concurrent diligence/program activities.
Qualifications (Required):
- Bachelor’s degree in Life Science or related field.
- Minimum 10 years relevant biopharmaceutical industry experience (or 6 years with PhD/MD/PharmD).
- Strong knowledge of pharmacology principles in nonclinical and clinical development.
- Experience evaluating drug candidates/MoA/disease biology/pharmacology to support development decisions and translational strategy.
- Working knowledge of regulatory expectations for nonclinical/translational support.
- Ability to synthesize complex data, identify risks/opportunities, and communicate clear recommendations.
Skills (Preferred/Additional):
- PhD, MD, PharmD or equivalent advanced degree (preferred).
- Experience in rare disease/rare metabolic disease/nephrology/immunology/inflammation.
- Prior formal business development due diligence experience.
- Experience with nonclinical toxicology and IND safety requirements (preferred).
- Translational plan experience (MoA→target engagement→PD→biomarkers→clinical outcomes).
- Familiarity with biomarker strategy, patient selection, human translational systems, and disease pharmacology models.
- Experience collaborating with CROs/academics/consultants and preparing executive-level diligence summaries.
Benefits:
- Premium health, financial, work-life/well-being offerings; wellness/support programs; life insurance; disability; retirement with employer match; generous paid time off.
- Target base pay range: $189,000–$246,000.
Application Instructions:
- Travere will accept applications on an ongoing basis until a candidate is selected.
Director, Translational Pharmacology (Research & Nonclinical Development). Serve as a key scientific contributor to external business development evaluation, assessing therapeutic rationale, disease biology, mechanism of action, translational strategy, pharmacology data, biomarker approaches, and development feasibility; support internal translational pharmacology activities as needed.
Responsibilities:
- Act as preclinical biology lead/key contributor for diligence of small-molecule through biologics opportunities (assets, platform tech, collaborations).
- Assess MoA, disease biology, pharmacology/toxicology, translational relevance, safety window, biomarker strategy, and development feasibility.
- Integrate nonclinical/translational with clinical, regulatory, and competitive data to identify strengths/risks/gaps/value drivers.
- Partner with BD and diligence teams to develop scientific assessment reports, diligence questions, risk summaries, and recommendations.
- Identify critical experiments/expert input to reduce scientific uncertainty.
- Provide translational pharmacology expertise across in vitro/in vivo/ex vivo, biomarkers, PD, and clinical pharmacology data.
- Evaluate target engagement, dose rationale, patient selection, and clinical development strategy.
- Engage external experts/companies/academia/CROs; represent company in scientific forums.
- Interpret data in regulatory/clinical context; evaluate adequacy of nonclinical packages.
- Support development plans/budgets; contribute to investigator brochures, briefing documents, regulatory submissions, and development documents.
- Identify nonclinical/translational gaps impacting timelines/regulatory strategy/probability of success.
- Provide scientific leadership, mentor colleagues, and manage multiple concurrent diligence/program activities.
Qualifications (Required):
- Bachelor’s degree in Life Science or related field.
- Minimum 10 years relevant biopharmaceutical industry experience (or 6 years with PhD/MD/PharmD).
- Strong knowledge of pharmacology principles in nonclinical and clinical development.
- Experience evaluating drug candidates/MoA/disease biology/pharmacology to support development decisions and translational strategy.
- Working knowledge of regulatory expectations for nonclinical/translational support.
- Ability to synthesize complex data, identify risks/opportunities, and communicate clear recommendations.
Skills (Preferred/Additional):
- PhD, MD, PharmD or equivalent advanced degree (preferred).
- Experience in rare disease/rare metabolic disease/nephrology/immunology/inflammation.
- Prior formal business development due diligence experience.
- Experience with nonclinical toxicology and IND safety requirements (preferred).
- Translational plan experience (MoA→target engagement→PD→biomarkers→clinical outcomes).
- Familiarity with biomarker strategy, patient selection, human translational systems, and disease pharmacology models.
- Experience collaborating with CROs/academics/consultants and preparing executive-level diligence summaries.
Benefits:
- Premium health, financial, work-life/well-being offerings; wellness/support programs; life insurance; disability; retirement with employer match; generous paid time off.
- Target base pay range: $189,000–$246,000.
Application Instructions:
- Travere will accept applications on an ongoing basis until a candidate is selected.