Director/Sr Director Pharmacometrics
Eli Lilly and Company
6 months ago
Remote friendly (Indianapolis, IN)
United States
Clinical Research and Development
Role Overview
- Operate as an enterprise-level scientific leader to define which scientific problems matter and shape PMx strategy across programs, platforms, and the broader organization.
- Serve as a trusted scientific partner to cross-functional leaders, PKPD colleagues, and senior leadership; influence drug development decisions and regulatory interactions.
Key Responsibilities
Scientific & Technical Leadership
- Champion model-informed drug development (MIDD) approaches across programs and platforms; deliver novel PMx strategies that shape drug development decisions.
- Resolve complex technical/scientific challenges with cross-program impact, including exposure-response, dose justification, and regulatory submission strategies (with PKPD lead and cross-functional teams).
- Engage proactively with regulatory agencies through meetings, responses, and advisory interactions.
Partnership & People Development
- Inspire and elevate scientists through scientific leadership and mentorship.
- Mentor scientists at all levels to build technical depth, scientific judgment, and confidence.
- Create conditions for others to succeed by sharing knowledge, opening doors, and investing in bench strength and organizational capability.
Automation, Innovation & AI Integration
- Champion adoption of automation tools and AI/ML approaches that deliver pragmatic, scalable value.
- Build PMx’s external reputation through publications and scientific leadership in industry and regulatory forums.
- Communicate complex science with executive presence to diverse audiences.
Basic Qualifications
- PhD in a relevant field (PMx, biological/pharmaceutical sciences, bioengineering, biostatistics, computer science/engineering, data science, or related) with 5+ years post-PhD experience.
- Experience in population PKPD modeling across multiple programs or development phases.
- Experience with NONMEM and/or Monolix, and R.
Additional Skills & Preferences
- Experience with mrgsolve, Julia, Phoenix NLME, and/or MATLAB.
- Ability to translate quantitative modeling outputs into clear scientific and regulatory narratives for cross-functional and non-specialist audiences.
- Proven track record influencing drug development and regulatory strategy via PMx analyses with impact beyond a single project.
- MIDD experience shaping technical strategy across programs/platforms, including regulatory submissions, health authority interactions, or governance.
- Strong mentorship/coaching skills.
- Active engagement with AI and automation in a PMx context; hands-on tool experience and judgment to translate innovation into practical scientific value.
- Strong organizational and self-management skills; ability to manage a complex portfolio and prioritize for maximum scientific impact.
Compensation & Benefits (as stated)
- Anticipated wage: $177,000 - $308,000.
- Company bonus eligibility for full-time equivalent employees (dependent on company and individual performance).
- Benefits may include: 401(k), pension, vacation, medical/dental/vision/prescription, flexible benefits, life insurance/death benefits, time off/leave, and well-being benefits (e.g., employee assistance program, fitness, employee clubs/activities).
Application / Accommodation Instructions
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation.
- Operate as an enterprise-level scientific leader to define which scientific problems matter and shape PMx strategy across programs, platforms, and the broader organization.
- Serve as a trusted scientific partner to cross-functional leaders, PKPD colleagues, and senior leadership; influence drug development decisions and regulatory interactions.
Key Responsibilities
Scientific & Technical Leadership
- Champion model-informed drug development (MIDD) approaches across programs and platforms; deliver novel PMx strategies that shape drug development decisions.
- Resolve complex technical/scientific challenges with cross-program impact, including exposure-response, dose justification, and regulatory submission strategies (with PKPD lead and cross-functional teams).
- Engage proactively with regulatory agencies through meetings, responses, and advisory interactions.
Partnership & People Development
- Inspire and elevate scientists through scientific leadership and mentorship.
- Mentor scientists at all levels to build technical depth, scientific judgment, and confidence.
- Create conditions for others to succeed by sharing knowledge, opening doors, and investing in bench strength and organizational capability.
Automation, Innovation & AI Integration
- Champion adoption of automation tools and AI/ML approaches that deliver pragmatic, scalable value.
- Build PMx’s external reputation through publications and scientific leadership in industry and regulatory forums.
- Communicate complex science with executive presence to diverse audiences.
Basic Qualifications
- PhD in a relevant field (PMx, biological/pharmaceutical sciences, bioengineering, biostatistics, computer science/engineering, data science, or related) with 5+ years post-PhD experience.
- Experience in population PKPD modeling across multiple programs or development phases.
- Experience with NONMEM and/or Monolix, and R.
Additional Skills & Preferences
- Experience with mrgsolve, Julia, Phoenix NLME, and/or MATLAB.
- Ability to translate quantitative modeling outputs into clear scientific and regulatory narratives for cross-functional and non-specialist audiences.
- Proven track record influencing drug development and regulatory strategy via PMx analyses with impact beyond a single project.
- MIDD experience shaping technical strategy across programs/platforms, including regulatory submissions, health authority interactions, or governance.
- Strong mentorship/coaching skills.
- Active engagement with AI and automation in a PMx context; hands-on tool experience and judgment to translate innovation into practical scientific value.
- Strong organizational and self-management skills; ability to manage a complex portfolio and prioritize for maximum scientific impact.
Compensation & Benefits (as stated)
- Anticipated wage: $177,000 - $308,000.
- Company bonus eligibility for full-time equivalent employees (dependent on company and individual performance).
- Benefits may include: 401(k), pension, vacation, medical/dental/vision/prescription, flexible benefits, life insurance/death benefits, time off/leave, and well-being benefits (e.g., employee assistance program, fitness, employee clubs/activities).
Application / Accommodation Instructions
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation.