Director/Sr. Director - Medicinal Chemistry (synthetic macrocycles)

Role: Senior/Director level in Medicinal Chemistry focused on macrocycles and peptides, supporting drug discovery across Cardiometabolic, Immunology, Neuroscience, and Oncology. Responsibilities include designing and synthesizing macrocyclic small molecules and peptides, applying SAR and ADME/DMPK principles to optimize pharmacokinetic profiles, and collaborating across disciplines to develop high-quality drug candidates. The role involves leveraging innovative strategies, including AI/ML, to address scientific challenges, guiding program strategy, and communicating findings effectively. Qualifications: Ph.D. in Medicinal Chemistry, Organic Chemistry, or related field with 8+ years (or BS/MS plus 15+ years experience) in pharma or biotech drug discovery. Preferred skills include hands-on experience in macrocyclic peptide/small molecule design, strong ADME/DMPK expertise, and track record of advancing programs to candidate selection. High-value: Macrocyclic peptides/small molecules, drug discovery, multi-therapeutic areas, cross-functional collaboration, innovative design methods, and communication of complex data. Work setup: Indianapolis or San Francisco; details on travel not specified.