Director/Sr. Director - Medicinal Chemistry (synthetic macrocycles)

Role: Senior/Director level leader in Medicinal Chemistry specializing in macrocyclic compounds and peptides within Lilly's Advanced Molecule Design team. Objectives: design and synthesize macrocyclic small molecules and peptides to support drug discovery across Cardiometabolic, Immunology, Neuroscience, and Oncology. Responsibilities: apply SAR and ADME/DMPK principles to optimize compound properties; collaborate cross-functionally on program strategy; resolve scientific challenges; lead or contribute to innovative tool development including AI/ML approaches; document and communicate findings effectively; drive continuous improvement initiatives. Requirements: Ph.D. in Medicinal Chemistry, Organic Chemistry, or related field with 8+ years (or BS/MS with 15+ years) in pharma/biotech drug discovery; hands-on experience with macrocyclic peptide/molecule design and synthesis; strong ADME/DMPK expertise; proven collaboration skills; excellent communication. Preferred: track record of progressing molecules to candidate selection, publications/patents, and experience in multiple therapeutic modalities, especially challenging targets. High-value specifics: focus on macrocyclic peptides/small molecules, multi-therapeutic areas, early to mid-stage development, innovation in synthetic and computational methods. Work setup: Indianapolis, IN or San Francisco, CA; no explicit travel details provided.