Director/Sr. Director/Exec. Director Computational Chemistry, Advanced Molecular Design
Eli Lilly and Company
2 months ago
On-site
San Francisco, CA
$193,500 - $338,800 USD yearly
Clinical Research and Development
Position Summary:
- Lilly’s Advanced Molecular Design (AMD) team is responsible for small molecule lead optimization with rapid progress toward new clinical candidates for patients in need. Apply computational chemistry tools in close collaboration with medicinal chemistry and structural biology.
Responsibilities:
- Structure-based design for lead/late-stage optimization of small molecule therapeutics across therapeutic areas
- Prioritize medicinal chemistry efforts through critical analysis and decision-making to enable focused, rapid progress
- Ensure timely delivery of data and results to project teams to support iterative design cycles
- Maintain critical timelines and set team expectations for efficient delivery of clinical candidates
- Contribute to higher-level decision-making, including prioritization of the small-molecule discovery portfolio
- Collaborate with AMD and therapeutic area leaders to move molecules from leads to quality drug candidates
- Evaluate external technologies and related business development opportunities
Basic Requirements:
- PhD in Chemistry, Biophysics, or related discipline with 6–15 years of Drug Discovery research experience
Additional Preferences:
- Deep computational chemistry background for compound optimization
- Proven cross-disciplinary collaboration (medicinal chemists, structural biologists, and others)
- Mentoring commitment for earlier-career computational chemists
- Desire to help patients in need; proven drug discovery success
- Ability to generate creative optimization hypotheses across projects
- Knowledge of small molecule-protein interactions, ADME, and toxicological considerations
- Stay current with industry developments and novel techniques (including AI/ML)
- Agility and adaptability to changing research priorities
Physical Demands/Travel:
- Office environment; travel may be required
Work Environment:
- Onsite in San Francisco, CA or Louisville, CO
Compensation/Benefits (as stated):
- Anticipated wage: $193,500 - $338,800
- Possible company bonus for full-time employees (depending on performance)
- Comprehensive benefits for eligible employees, including 401(k), pension, vacation, medical/dental/vision/prescription, flexible benefits, life insurance, time off/leave, and well-being benefits
Application Instructions:
- Not provided in the text
- Lilly’s Advanced Molecular Design (AMD) team is responsible for small molecule lead optimization with rapid progress toward new clinical candidates for patients in need. Apply computational chemistry tools in close collaboration with medicinal chemistry and structural biology.
Responsibilities:
- Structure-based design for lead/late-stage optimization of small molecule therapeutics across therapeutic areas
- Prioritize medicinal chemistry efforts through critical analysis and decision-making to enable focused, rapid progress
- Ensure timely delivery of data and results to project teams to support iterative design cycles
- Maintain critical timelines and set team expectations for efficient delivery of clinical candidates
- Contribute to higher-level decision-making, including prioritization of the small-molecule discovery portfolio
- Collaborate with AMD and therapeutic area leaders to move molecules from leads to quality drug candidates
- Evaluate external technologies and related business development opportunities
Basic Requirements:
- PhD in Chemistry, Biophysics, or related discipline with 6–15 years of Drug Discovery research experience
Additional Preferences:
- Deep computational chemistry background for compound optimization
- Proven cross-disciplinary collaboration (medicinal chemists, structural biologists, and others)
- Mentoring commitment for earlier-career computational chemists
- Desire to help patients in need; proven drug discovery success
- Ability to generate creative optimization hypotheses across projects
- Knowledge of small molecule-protein interactions, ADME, and toxicological considerations
- Stay current with industry developments and novel techniques (including AI/ML)
- Agility and adaptability to changing research priorities
Physical Demands/Travel:
- Office environment; travel may be required
Work Environment:
- Onsite in San Francisco, CA or Louisville, CO
Compensation/Benefits (as stated):
- Anticipated wage: $193,500 - $338,800
- Possible company bonus for full-time employees (depending on performance)
- Comprehensive benefits for eligible employees, including 401(k), pension, vacation, medical/dental/vision/prescription, flexible benefits, life insurance, time off/leave, and well-being benefits
Application Instructions:
- Not provided in the text