Director, Small Molecule Discovery Biology (Inflammation & Autoimmunity)

Role: Director of autoimmune discovery biology responsible for leading small molecule drug discovery efforts targeting autoimmune diseases. Main objectives include shaping project strategies, identifying new targets, developing biochemical and cellular assays, and supporting characterization of clinical candidates. Responsibilities encompass overseeing biology projects, collaborating with cross-functional teams (medicinal chemistry, DMPK, preclinical), managing CRO external studies, and mentoring junior staff. Qualifications: PhD with 8+ years in immunology-related small molecule drug discovery, with experience in target validation, mechanism of action, and autoimmune models. Skills include expertise in emerging small molecule modalities (protein-protein interaction inhibitors, degraders, transcription factors), and familiarity with techniques like transcriptomics, proteomics, cytokine assays, and immune cell analysis. Preferred experience involves project leadership, managing CRO collaborations, and working across discovery to early clinical stages. High-value specifics: focus on autoimmune diseases, early-stage to preclinical development, small molecule modalities, and immunology expertise. Collaboration with cross-disciplinary teams and external CROs is essential. Location and travel details are not specified.