Director, Site Operations & Strategic Execution
Denali Therapeutics
August 06, 2026
On-site
Salt Lake City, UT
Operations
Director, Site Operations & Strategic Execution
Key Accountabilities / Core Responsibilities
- Lead and continuously improve the SLC Site Operating Model, including governance, operational processes, decision frameworks, performance management, and cross-functional execution governance.
- Partner with Site Leadership and enterprise teams to align site execution with strategic priorities across manufacturing, quality, supply chain, engineering, and technical operations.
- Establish and manage operational governance forums, business reviews, metrics, dashboards, and reporting processes for visibility, accountability, risk management, and data-driven decision-making.
- Lead strategic initiatives and continuous improvement efforts to strengthen operational readiness, scalability, organizational agility, and long-term commercial growth.
- Facilitate cross-functional coordination, resource planning and prioritization, issue resolution, and coach/mentor/develop project leadership and operational execution within the SLC organization.
- Identify operational risks, execution gaps, and inefficiencies; drive mitigation and continuous operational improvement.
Qualifications / Skills
- Bachelor’s degree in Engineering, Life Sciences, Operations, Supply Chain, Business, or related field; 10+ years in biotech/pharma manufacturing, technical operations, supply chain, or operational leadership.
- Advanced degree preferred.
- GMP-regulated environment experience leading complex cross-functional operational initiatives.
- Strong understanding of biopharmaceutical manufacturing, technical operations, commercialization readiness, and/or late-stage development.
- Experience with operational governance models, business processes, performance management systems, and operating cadences.
- Ability to influence stakeholders without direct authority; lead in fast-paced, ambiguous environments.
- Strong strategic thinking, operational problem-solving, and executive communication.
- Preferred: experience with operational metrics/dashboards; manufacturing readiness, PPQ execution, launch readiness, or operational scale-up.
- Working knowledge of GMP and FDA/international regulatory requirements; ability to travel as required.
Benefits (as stated)
- Competitive total rewards package including 401k, healthcare coverage, and ESPP.
Key Accountabilities / Core Responsibilities
- Lead and continuously improve the SLC Site Operating Model, including governance, operational processes, decision frameworks, performance management, and cross-functional execution governance.
- Partner with Site Leadership and enterprise teams to align site execution with strategic priorities across manufacturing, quality, supply chain, engineering, and technical operations.
- Establish and manage operational governance forums, business reviews, metrics, dashboards, and reporting processes for visibility, accountability, risk management, and data-driven decision-making.
- Lead strategic initiatives and continuous improvement efforts to strengthen operational readiness, scalability, organizational agility, and long-term commercial growth.
- Facilitate cross-functional coordination, resource planning and prioritization, issue resolution, and coach/mentor/develop project leadership and operational execution within the SLC organization.
- Identify operational risks, execution gaps, and inefficiencies; drive mitigation and continuous operational improvement.
Qualifications / Skills
- Bachelor’s degree in Engineering, Life Sciences, Operations, Supply Chain, Business, or related field; 10+ years in biotech/pharma manufacturing, technical operations, supply chain, or operational leadership.
- Advanced degree preferred.
- GMP-regulated environment experience leading complex cross-functional operational initiatives.
- Strong understanding of biopharmaceutical manufacturing, technical operations, commercialization readiness, and/or late-stage development.
- Experience with operational governance models, business processes, performance management systems, and operating cadences.
- Ability to influence stakeholders without direct authority; lead in fast-paced, ambiguous environments.
- Strong strategic thinking, operational problem-solving, and executive communication.
- Preferred: experience with operational metrics/dashboards; manufacturing readiness, PPQ execution, launch readiness, or operational scale-up.
- Working knowledge of GMP and FDA/international regulatory requirements; ability to travel as required.
Benefits (as stated)
- Competitive total rewards package including 401k, healthcare coverage, and ESPP.