Director, RWE Scientist
Crinetics Pharmaceuticals
June 30, 2026
Remote friendly (United States)
United States
Clinical Research and Development
Position Summary
Director, Real-World Evidence (RWE) Scientist designs, executes, and delivers RWE studies for the atumelnant program (CAH adult/pediatric, Cushing’s disease) through launch and lifecycle management.
Essential Job Functions and Responsibilities
- Design and execute observational RWE studies: burden of illness, natural history, patient journey, treatment patterns, drug utilization, external control arms, comparative effectiveness.
- Own and steward CAH real-world data assets (cohorts, code lists, analytic datasets) for continuity and reusability.
- Lead analyses using claims/EHR/registries/linked datasets and primary RWD (chart reviews, surveys).
- Develop protocols, SAPs, feasibility assessments; select databases and confirm variable/patient availability.
- Ensure continuity of atumelnant RWE through launch; translate HEOR/RWE TA evidence priorities into executable analyses.
- Apply causal-inference and bias-control methods for observational data.
- Mentor external analysts; oversee study vendors/CROs (scope, timelines, budget, quality).
- Contribute outputs to evidence plans, value dossiers, and HTA submissions; collaborate with internal/external partners.
- Publish and present findings; ensure compliance with policies and US healthcare laws/regulations.
Required Qualifications
- PhD/MD/PharmD/MPH/MSc in epidemiology, biostatistics, health services research, health economics, or related field.
- 10+ years pharmaceutical/biotech/HEOR experience executing observational research.
- Expertise designing/executing observational studies with large real-world datasets.
- Strong RWE analytics/programming knowledge (R preferred; SQL/SAS/Python valued) and causal-methods expertise.
- Feasibility/database selection experience; experience leading teams and overseeing external analysts/vendors.
- Knowledge of regulatory/HTA RWE expectations (FDA RWE Framework; ISPOR/ISPE).
- Strong communication skills; cross-functional collaboration; compliance focus.
Preferred Qualifications
- Rare/specialty endocrine or niche-population experience.
- Familiarity with CAH/Cushing’s; external control arms and target trial emulation.
- AI/ML phenotyping or modern RWE analytics platforms.
Benefits (as stated)
- Discretionary annual target bonus, stock options, ESPP, 401(k) match; health insurance (medical/dental/vision/basic life), 20 days PTO, 10 paid holidays, winter company shutdown.
Travel
- Up to 5%.
Director, Real-World Evidence (RWE) Scientist designs, executes, and delivers RWE studies for the atumelnant program (CAH adult/pediatric, Cushing’s disease) through launch and lifecycle management.
Essential Job Functions and Responsibilities
- Design and execute observational RWE studies: burden of illness, natural history, patient journey, treatment patterns, drug utilization, external control arms, comparative effectiveness.
- Own and steward CAH real-world data assets (cohorts, code lists, analytic datasets) for continuity and reusability.
- Lead analyses using claims/EHR/registries/linked datasets and primary RWD (chart reviews, surveys).
- Develop protocols, SAPs, feasibility assessments; select databases and confirm variable/patient availability.
- Ensure continuity of atumelnant RWE through launch; translate HEOR/RWE TA evidence priorities into executable analyses.
- Apply causal-inference and bias-control methods for observational data.
- Mentor external analysts; oversee study vendors/CROs (scope, timelines, budget, quality).
- Contribute outputs to evidence plans, value dossiers, and HTA submissions; collaborate with internal/external partners.
- Publish and present findings; ensure compliance with policies and US healthcare laws/regulations.
Required Qualifications
- PhD/MD/PharmD/MPH/MSc in epidemiology, biostatistics, health services research, health economics, or related field.
- 10+ years pharmaceutical/biotech/HEOR experience executing observational research.
- Expertise designing/executing observational studies with large real-world datasets.
- Strong RWE analytics/programming knowledge (R preferred; SQL/SAS/Python valued) and causal-methods expertise.
- Feasibility/database selection experience; experience leading teams and overseeing external analysts/vendors.
- Knowledge of regulatory/HTA RWE expectations (FDA RWE Framework; ISPOR/ISPE).
- Strong communication skills; cross-functional collaboration; compliance focus.
Preferred Qualifications
- Rare/specialty endocrine or niche-population experience.
- Familiarity with CAH/Cushing’s; external control arms and target trial emulation.
- AI/ML phenotyping or modern RWE analytics platforms.
Benefits (as stated)
- Discretionary annual target bonus, stock options, ESPP, 401(k) match; health insurance (medical/dental/vision/basic life), 20 days PTO, 10 paid holidays, winter company shutdown.
Travel
- Up to 5%.