Director, R&D Chemistry

Role Summary

Director, R&D Chemistry – Lead and innovate in expanding small molecule and peptidomimetic antibody-conjugate drug discovery capabilities, integrating with biologics and genetic medicines expertise. Drive multi-modality antibody conjugate therapeutics across oncology, metabolic disease, infectious disease, immunology and inflammation, neuroscience, and ophthalmology. Lead a collaborative team of synthetic organic, medicinal chemistry and bioconjugation scientists to develop antibody-targeted drug therapeutics with optimal in vitro and in vivo properties.

Responsibilities

• Directly supervise and manage the day-to-day activities of the R&D Chemistry group, providing vision, inspiration, and both short-term and long-term goals. Communicate priorities, policies, and goals of Regeneron Senior Leaders to the group.
• Perform medicinal chemistry SAR-driven optimization of novel small molecule and peptidomimetic drug modalities to provide overall optimal in vitro and in vivo properties of the antibody-targeted therapeutics
• Champion and lead the R&D chemistry efforts on multiple internal/external project teams, and demonstrate the ability to multi-task and parallel process to add to our continuous pipeline of Regeneron development candidates
• Identify new strategies and technologies and improve on existing Regeneron platforms for pursuing novel synthesis and bioconjugation of small molecule and peptidomimetic drug modalities
• Set priorities, accelerate, and ensure successful progression of the group‚Äôs technology and pipeline projects.
• Actively participate in departmental, cross-functional, senior leadership, and external meetings to contribute expertise and to represent the goals and vision of the R&D Chemistry group.
• Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations.
• Challenge and mentor the R&D Chemistry group to provide opportunities, visibility, and development for all group members.

Qualifications

• Have a Ph.D. in synthetic organic chemistry (or related), extensive drug discovery experience with antibody-targeted small molecule and peptidomimetic drug modalities including their synthesis and manufacturing, and expertise in modern methods in medicinal chemistry structure-activity relationships.
• Additional relevant experience should include a deep understanding of biological MOAs, extracellular/intracellular target evaluation, ADME/PK, PD/efficacy, tox evaluation, and a minimum of 10 years of industry experience.
• A track record of success in the field of small molecules, peptidomimetics, or antibody targeted therapeutics (i.e., advancement of molecules into the clinic), with experience building and leading teams is required.
• Working collaboratively with both internal and external organizations (e.g., CROs) is essential.

Skills

• Synthetic organic/medicinal chemistry
• Bioconjugation techniques, platforms, and strategies
• SAR optimization and multi-disciplinary collaboration
• Chemical biology strategies and integration of chemical/biological solutions
• Leadership, communication, and cross-functional collaboration