Director, R&D Chemistry

Role Summary

Director, R&D Chemistry – Lead the R&D Chemistry group to expand Regeneron’s small molecule and peptidomimetic antibody-conjugate drug discovery capabilities, integrating with biologics and novel genetic medicines, and driving multi-modality antibody-targeted therapeutics across multiple disease areas.

Responsibilities

• Directly supervise and manage day-to-day activities of the R&D Chemistry group, setting vision and short-/long-term goals; communicate priorities and goals to the group.
• Perform medicinal chemistry SAR-driven optimization of novel small molecule and peptidomimetic modalities to optimize in vitro and in vivo properties of antibody-targeted therapeutics.
• Champion and lead R&D chemistry efforts on multiple project teams, prioritizing and parallel processing to sustain the development pipeline.
• Identify new strategies/technologies and improve existing platforms for synthesis and bioconjugation of small molecule and peptidomimetic modalities.
• Set priorities and accelerate progression of the group’s technology and pipeline projects.
• Participate in departmental, cross-functional, senior leadership, and external meetings to contribute expertise and represent the R&D Chemistry group’s goals and vision.
• Interact broadly with other Regeneron groups, forging relationships and collaborations.
• Mentor the R&D Chemistry group to provide opportunities, visibility, and development for all members.

Qualifications

• Ph.D. in synthetic organic chemistry (or related) with extensive drug discovery experience in antibody-targeted small molecule and peptidomimetic modalities, including synthesis and manufacturing, and expertise in medicinal chemistry SAR.
• Deep understanding of MOAs, target evaluation, ADME/PK, PD/efficacy, tox evaluation; minimum 10 years of industry experience.
• Proven track record in small molecules, peptidomimetics, or antibody-targeted therapeutics with experience building and leading teams; ability to collaborate with internal and external partners (e.g., CROs).

Skills

• Synthetic organic/medicinal chemistry with expertise in antibody linker-payload synthesis
• Bioconjugation techniques, platforms, and strategies for small molecule and peptidomimetic modalities
• Chemical biology strategies integrating chemical and biological solutions in drug discovery
• Leadership, communication, and cross-functional collaboration

Education

• Ph.D. in synthetic organic chemistry or related field