Director, Quantitative Pharmacology and Pharmacometrics – Oncology
Merck
August 14, 2026
Remote friendly (North Wales, PA)
United States
Clinical Research and Development
Director, Quantitative Pharmacology and Pharmacometrics – Immune/Oncology (QP2-IO)
Primary Responsibilities:
- Serve as an expert representative for QP2-IO on Oncology development teams.
- Frame critical questions and strategy to optimize model-based analyses.
- Develop and execute model-based analyses, including translational PK/PD, population PK, exposure-response, clinical trial design simulations, disease progression models, QSP modeling, and comparator modeling.
- Strategize and execute modeling of tumor size and survival.
- Maintain knowledge of global regulatory expectations in Oncology; author regulatory documents (INDs, CSRs, CTDs) and represent QP2-IO at regulatory meetings.
- Mentor and/or supervise junior staff.
Minimum Education Required:
- Ph.D. with at least 7 years of pharmaceutical drug development experience in PK/PD, pharmacometrics, math, statistics/biostatistics, or chemical/biomedical engineering.
- OR Masters or PharmD with at least 9 years of experience with increasing responsibility and independence in similar pharmaceutical drug development roles.
Required Experience/Qualifications:
- Demonstrated impact using pharmacometrics methods.
- Experience with IND/NDA and other submissions to global regulatory agencies.
- Skills in experimental design, mathematical problem solving, data analysis/interpretation, and statistics.
- Increasing responsibility/independence and impact driving drug development decisions with model-based approaches.
- Proficiency in R, NONMEM, MATLAB, Monolix or other modeling software.
- Professional written and verbal communication.
Required Skills (role): Clinical pharmacology; communication; data modeling; data visualization; drug development; modeling software; pharmacology; pharmacometrics; program leadership; stakeholder relationship management.
Preferred Skills:
- Antibody drug conjugates (ADC), biologics, oncology, small molecule drugs, T cells.
Application:
- Apply via https://jobs.merck.com/us/en (or Workday Jobs Hub for current employees). Requisition ID: R409526.
Primary Responsibilities:
- Serve as an expert representative for QP2-IO on Oncology development teams.
- Frame critical questions and strategy to optimize model-based analyses.
- Develop and execute model-based analyses, including translational PK/PD, population PK, exposure-response, clinical trial design simulations, disease progression models, QSP modeling, and comparator modeling.
- Strategize and execute modeling of tumor size and survival.
- Maintain knowledge of global regulatory expectations in Oncology; author regulatory documents (INDs, CSRs, CTDs) and represent QP2-IO at regulatory meetings.
- Mentor and/or supervise junior staff.
Minimum Education Required:
- Ph.D. with at least 7 years of pharmaceutical drug development experience in PK/PD, pharmacometrics, math, statistics/biostatistics, or chemical/biomedical engineering.
- OR Masters or PharmD with at least 9 years of experience with increasing responsibility and independence in similar pharmaceutical drug development roles.
Required Experience/Qualifications:
- Demonstrated impact using pharmacometrics methods.
- Experience with IND/NDA and other submissions to global regulatory agencies.
- Skills in experimental design, mathematical problem solving, data analysis/interpretation, and statistics.
- Increasing responsibility/independence and impact driving drug development decisions with model-based approaches.
- Proficiency in R, NONMEM, MATLAB, Monolix or other modeling software.
- Professional written and verbal communication.
Required Skills (role): Clinical pharmacology; communication; data modeling; data visualization; drug development; modeling software; pharmacology; pharmacometrics; program leadership; stakeholder relationship management.
Preferred Skills:
- Antibody drug conjugates (ADC), biologics, oncology, small molecule drugs, T cells.
Application:
- Apply via https://jobs.merck.com/us/en (or Workday Jobs Hub for current employees). Requisition ID: R409526.